| http://purl.uniprot.org/citations/23851690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23851690 | http://www.w3.org/2000/01/rdf-schema#comment | "Class switch DNA recombination (CSR) crucially diversifies Ab biologic effector functions. 14-3-3γ specifically binds to the 5'-AGCT-3' repeats in the IgH locus switch (S) regions. By interacting directly with the C-terminal region of activation-induced cytidine deaminase (AID), 14-3-3γ targets this enzyme to S regions to mediate CSR. In this study, we showed that 14-3-3γ was expressed in germinal center B cells in vivo and induced in B cells by T-dependent and T-independent primary CSR-inducing stimuli in vitro in humans and mice. Induction of 14-3-3γ was rapid, peaking within 3 h of stimulation by LPSs, and sustained over the course of AID and CSR induction. It was dependent on recruitment of NF-κB to the 14-3-3γ gene promoter. The NF-κB recruitment enhanced the occupancy of the CpG island within the 14-3-3γ promoter by CFP1, a component of the COMPASS histone methyltransferase complex, and promoter-specific enrichment of histone 3 lysine 4 trimethylation (H3K4me3), which is indicative of open chromatin state and marks transcription-competent promoters. NF-κB also potentiated the binding of B cell lineage-specific factor E2A to an E-box motif located immediately downstream of the two closely-spaced transcription start sites for sustained 14-3-3γ expression and CSR induction. Thus, 14-3-3γ induction in CSR is enabled by the CFP1-mediated H3K4me3 enrichment in the promoter, dependent on NF-κB and sustained by E2A."xsd:string |
| http://purl.uniprot.org/citations/23851690 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.1300922"xsd:string |
| http://purl.uniprot.org/citations/23851690 | http://purl.uniprot.org/core/author | "Li G."xsd:string |
| http://purl.uniprot.org/citations/23851690 | http://purl.uniprot.org/core/author | "Xu Z."xsd:string |
| http://purl.uniprot.org/citations/23851690 | http://purl.uniprot.org/core/author | "Casali P."xsd:string |
| http://purl.uniprot.org/citations/23851690 | http://purl.uniprot.org/core/author | "Lam T.S."xsd:string |
| http://purl.uniprot.org/citations/23851690 | http://purl.uniprot.org/core/author | "Pone E.J."xsd:string |
| http://purl.uniprot.org/citations/23851690 | http://purl.uniprot.org/core/author | "Mai T."xsd:string |
| http://purl.uniprot.org/citations/23851690 | http://purl.uniprot.org/core/author | "Moehlman J."xsd:string |
| http://purl.uniprot.org/citations/23851690 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23851690 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/23851690 | http://purl.uniprot.org/core/pages | "1895-1906"xsd:string |
| http://purl.uniprot.org/citations/23851690 | http://purl.uniprot.org/core/title | "Induction of activation-induced cytidine deaminase-targeting adaptor 14-3-3gamma is mediated by NF-kappaB-dependent recruitment of CFP1 to the 5'-CpG-3'-rich 14-3-3gamma promoter and is sustained by E2A."xsd:string |
| http://purl.uniprot.org/citations/23851690 | http://purl.uniprot.org/core/volume | "191"xsd:string |
| http://purl.uniprot.org/citations/23851690 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23851690 |
| http://purl.uniprot.org/citations/23851690 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23851690 |
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| http://purl.uniprot.org/uniprot/#_A0A0R4J014-mappedCitation-23851690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23851690 |
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| http://purl.uniprot.org/uniprot/#_E9PWE4-mappedCitation-23851690 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23851690 |