| http://purl.uniprot.org/citations/23852341 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23852341 | http://www.w3.org/2000/01/rdf-schema#comment | "The B cell-specific transcription factor BACH2 is required for affinity maturation of B cells. Here we show that Bach2-mediated activation of p53 is required for stringent elimination of pre-B cells that failed to productively rearrange immunoglobulin VH-DJH gene segments. After productive VH-DJH gene rearrangement, pre-B cell receptor signaling ends BACH2-mediated negative selection through B cell lymphoma 6 (BCL6)-mediated repression of p53. In patients with pre-B acute lymphoblastic leukemia, the BACH2-mediated checkpoint control is compromised by deletions, rare somatic mutations and loss of its upstream activator, PAX5. Low levels of BACH2 expression in these patients represent a strong independent predictor of poor clinical outcome. In this study, we demonstrate that Bach2(+/+) pre-B cells resist leukemic transformation by Myc through Bach2-dependent upregulation of p53 and do not initiate fatal leukemia in transplant-recipient mice. Chromatin immunoprecipitation sequencing and gene expression analyses carried out by us revealed that BACH2 competes with BCL6 for promoter binding and reverses BCL6-mediated repression of p53 and other cell cycle checkpoint-control genes. These findings identify BACH2 as a crucial mediator of negative selection at the pre-B cell receptor checkpoint and a safeguard against leukemogenesis."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.org/dc/terms/identifier | "doi:10.1038/nm.3247"xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Chen Z."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Igarashi K."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Kang H."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Huang C."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Swaminathan S."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Titz B."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Ng C."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Rand V."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Harvey R."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Geng H."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Carroll W.L."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Sadiyah M.F."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Melnick A."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Muschen M."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Koeffler H.P."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Willman C.L."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Nowak D."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Hall A.G."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Graeber T.G."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Hurtz C."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/author | "Thoennissen G.B."xsd:string |
| http://purl.uniprot.org/citations/23852341 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |