http://purl.uniprot.org/citations/23855785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
http://purl.uniprot.org/citations/23855785 | http://www.w3.org/2000/01/rdf-schema#comment | "AimsIn this study, we aimed to investigate the molecular mechanisms underlying the development of mucoepidermoid carcinoma (MEC).Methods and resultsIn 31 cases, we examined the MAML2 fusion status using reverse transcriptase-polymerase chain reaction, and HER2 and EGFR status using immunohistochemistry and chromogenic in-situ hybridization. MAML2 fusions were detected in 15 (57.7%) of 26 MECs analysed, including 11 of 16 (68.8%) low-grade, two of four (50%) intermediate-grade and two of six (33.3%) high-grade MECs. HER2 gene amplification and an increased EGFR gene copy number (with balanced chromosome 7 high-polysomy) were each detected in four of 28 (14.3%) MECs analysed. Irrespective of MAML2 fusion status, all seven high-grade MECs had an increased gene copy number of either HER2 or EGFR, in a mutually exclusive manner, whereas such abnormalities were extremely rare in low- and intermediate-grade MEC.ConclusionsThese results suggest that HER2 or EGFR gene abnormality could play an important role in the development of high-grade MEC, and also in the progression from MAML2 fusion-positive low-/intermediate-grade to high-grade in a subset of MEC. Furthermore, we suggest that high-grade MEC comprises a heterogeneous group of tumours in terms of molecular pathogenesis, in particular MAML2 fusion status."xsd:string |
http://purl.uniprot.org/citations/23855785 | http://purl.org/dc/terms/identifier | "doi:10.1111/his.12183"xsd:string |
http://purl.uniprot.org/citations/23855785 | http://purl.uniprot.org/core/author | "Hashimoto K."xsd:string |
http://purl.uniprot.org/citations/23855785 | http://purl.uniprot.org/core/author | "Oda Y."xsd:string |
http://purl.uniprot.org/citations/23855785 | http://purl.uniprot.org/core/author | "Yamamoto H."xsd:string |
http://purl.uniprot.org/citations/23855785 | http://purl.uniprot.org/core/author | "Nakashima T."xsd:string |
http://purl.uniprot.org/citations/23855785 | http://purl.uniprot.org/core/author | "Nakano T."xsd:string |
http://purl.uniprot.org/citations/23855785 | http://purl.uniprot.org/core/author | "Nishiyama K."xsd:string |
http://purl.uniprot.org/citations/23855785 | http://purl.uniprot.org/core/author | "Higaki Y."xsd:string |
http://purl.uniprot.org/citations/23855785 | http://purl.uniprot.org/core/author | "Tamiya S."xsd:string |
http://purl.uniprot.org/citations/23855785 | http://purl.uniprot.org/core/author | "Shiratsuchi H."xsd:string |
http://purl.uniprot.org/citations/23855785 | http://purl.uniprot.org/core/author | "Komune S."xsd:string |
http://purl.uniprot.org/citations/23855785 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
http://purl.uniprot.org/citations/23855785 | http://purl.uniprot.org/core/name | "Histopathology"xsd:string |
http://purl.uniprot.org/citations/23855785 | http://purl.uniprot.org/core/pages | "378-392"xsd:string |
http://purl.uniprot.org/citations/23855785 | http://purl.uniprot.org/core/title | "HER2 and EGFR gene copy number alterations are predominant in high-grade salivary mucoepidermoid carcinoma irrespective of MAML2 fusion status."xsd:string |
http://purl.uniprot.org/citations/23855785 | http://purl.uniprot.org/core/volume | "63"xsd:string |
http://purl.uniprot.org/citations/23855785 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23855785 |
http://purl.uniprot.org/citations/23855785 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23855785 |
http://purl.uniprot.org/uniprot/#_A0A068JD88-mappedCitation-23855785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23855785 |
http://purl.uniprot.org/uniprot/#_A8K2T7-mappedCitation-23855785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23855785 |
http://purl.uniprot.org/uniprot/#_A0A068JCC9-mappedCitation-23855785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23855785 |
http://purl.uniprot.org/uniprot/#_A0A1Y0B9F8-mappedCitation-23855785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23855785 |
http://purl.uniprot.org/uniprot/#_A0A1Y0B9F6-mappedCitation-23855785 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23855785 |