| http://purl.uniprot.org/citations/23859071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23859071 | http://www.w3.org/2000/01/rdf-schema#comment | "To identify genetic risks for obesity and diabetes postliver transplantation (LT), LT recipients underwent genotyping for IL28B rs12979860 (n = 295) and PNPLA3 rs738409 (n = 205) polymorphism in both donors and recipients. The development of obesity and diabetes/impaired fasting glucose (IFG) was determined 1-5 years post-LT. Recipient PNPLA-3 genotype was independently associated with obesity (BMI > 30) at 3 years posttransplant (genotype CC 33.7%, CG 48.3% and GG 82.4%, p = 0.002), with an odds ratio (OR 2.54, CI 1.38-4.66, p = 0.003), associated with the G allele. Diabetes/IFG diagnosed within 5 years posttransplant associated with PNPLA-3 non-CC genotype (HR 1.59, 1.12-2.26, p = 0.010), but not IL28B TT genotype (HR 1.46, 0.94-2.27, p = 0.092). No genotype variable was independently predictive of diabetes/IFG. The combination of PNPLA-3 non-CC and IL28B TT genotype was associated with increased risk of diabetes/IFG compared to PNPLA-3 CC, IL28B non-TT (HR 2.64, CI 1.30-5.39, p = 0.008). Donor genotypes were not associated with any of the outcomes analyzed. In conclusion, PNPLA-3 non-CC genotype is associated with posttransplant obesity but not independently with diabetes/IFG. The lack of donor related risk suggests a peripheral rather than central mechanism of insulin resistance in liver transplant recipients."xsd:string |
| http://purl.uniprot.org/citations/23859071 | http://purl.org/dc/terms/identifier | "doi:10.1111/ajt.12355"xsd:string |
| http://purl.uniprot.org/citations/23859071 | http://purl.uniprot.org/core/author | "Fan C."xsd:string |
| http://purl.uniprot.org/citations/23859071 | http://purl.uniprot.org/core/author | "Thompson A."xsd:string |
| http://purl.uniprot.org/citations/23859071 | http://purl.uniprot.org/core/author | "Krishnan A."xsd:string |
| http://purl.uniprot.org/citations/23859071 | http://purl.uniprot.org/core/author | "Tillman H."xsd:string |
| http://purl.uniprot.org/citations/23859071 | http://purl.uniprot.org/core/author | "Goldstein D."xsd:string |
| http://purl.uniprot.org/citations/23859071 | http://purl.uniprot.org/core/author | "Heimbach J.K."xsd:string |
| http://purl.uniprot.org/citations/23859071 | http://purl.uniprot.org/core/author | "Charlton M.R."xsd:string |
| http://purl.uniprot.org/citations/23859071 | http://purl.uniprot.org/core/author | "Dierkhising R."xsd:string |
| http://purl.uniprot.org/citations/23859071 | http://purl.uniprot.org/core/author | "Watt K.D."xsd:string |
| http://purl.uniprot.org/citations/23859071 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23859071 | http://purl.uniprot.org/core/name | "Am J Transplant"xsd:string |
| http://purl.uniprot.org/citations/23859071 | http://purl.uniprot.org/core/pages | "2450-2457"xsd:string |
| http://purl.uniprot.org/citations/23859071 | http://purl.uniprot.org/core/title | "Investigation of PNPLA3 and IL28B genotypes on diabetes and obesity after liver transplantation: insight into mechanisms of disease."xsd:string |
| http://purl.uniprot.org/citations/23859071 | http://purl.uniprot.org/core/volume | "13"xsd:string |
| http://purl.uniprot.org/citations/23859071 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23859071 |
| http://purl.uniprot.org/citations/23859071 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23859071 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DGW8-mappedCitation-23859071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23859071 |
| http://purl.uniprot.org/uniprot/#_A0A7R8C2Z6-mappedCitation-23859071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23859071 |
| http://purl.uniprot.org/uniprot/#_Q8IZI9-mappedCitation-23859071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23859071 |
| http://purl.uniprot.org/uniprot/#_Q9NST1-mappedCitation-23859071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23859071 |
| http://purl.uniprot.org/uniprot/#_U3N4F2-mappedCitation-23859071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23859071 |
| http://purl.uniprot.org/uniprot/#_U3N901-mappedCitation-23859071 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23859071 |