Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/23859711http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23859711http://www.w3.org/2000/01/rdf-schema#comment"

Aims

The aim of this study was to perform combined analyses of six genetic variants for the risk of hypertension.

Methods

After a comprehensive literature search for genetic variants involved with the association study of hypertension, we harvested a total of five genes (six variants) for the current meta-analyses. These genes consisted of CYP4A11 (T8590C), RGS2 (1891-1892del TC and G638A), HTR2A (T102C), GNAS (T393C), and HSD3B1 (T→C Leu338).

Results

A total of 20 studies among 13,816 cases and 19,248 controls were retrieved for the meta-analyses of six genetic variants. It was shown that the RGS2 1891-1892del TC (OR=1.10, 95% CI=1.02-1.19, p=0.02) polymorphism and the CYP4A11 T8590C (OR=1.19, 95% CI=1.00-1.41, p=0.05) polymorphism were significantly associated with increased risk of hypertension. No association was found between the other four variants and the risk of hypertension.

Conclusion

This meta-analysis revealed that the RGS2 1891-1892del TC polymorphism and CYP4A11 T8590C polymorphism were associated with hypertension risk. However, HSD3B1 T→C Leu338, HTR2A T102C, GNAS T393C, and RGS2 G638A polymorphisms were not associated with hypertension risk."xsd:string
http://purl.uniprot.org/citations/23859711http://purl.org/dc/terms/identifier"doi:10.1089/gtmb.2013.0080"xsd:string
http://purl.uniprot.org/citations/23859711http://purl.uniprot.org/core/author"Chen C."xsd:string
http://purl.uniprot.org/citations/23859711http://purl.uniprot.org/core/author"Duan S."xsd:string
http://purl.uniprot.org/citations/23859711http://purl.uniprot.org/core/author"Xu L."xsd:string
http://purl.uniprot.org/citations/23859711http://purl.uniprot.org/core/author"Wang L."xsd:string
http://purl.uniprot.org/citations/23859711http://purl.uniprot.org/core/author"Zhang C."xsd:string
http://purl.uniprot.org/citations/23859711http://purl.uniprot.org/core/author"Zhang L."xsd:string
http://purl.uniprot.org/citations/23859711http://purl.uniprot.org/core/author"Xu X."xsd:string
http://purl.uniprot.org/citations/23859711http://purl.uniprot.org/core/author"Ye M."xsd:string
http://purl.uniprot.org/citations/23859711http://purl.uniprot.org/core/author"Ye H."xsd:string
http://purl.uniprot.org/citations/23859711http://purl.uniprot.org/core/author"Liao Q."xsd:string
http://purl.uniprot.org/citations/23859711http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23859711http://purl.uniprot.org/core/name"Genet Test Mol Biomarkers"xsd:string
http://purl.uniprot.org/citations/23859711http://purl.uniprot.org/core/pages"736-742"xsd:string
http://purl.uniprot.org/citations/23859711http://purl.uniprot.org/core/title"Genetic associations with hypertension: meta-analyses of six candidate genetic variants."xsd:string
http://purl.uniprot.org/citations/23859711http://purl.uniprot.org/core/volume"17"xsd:string
http://purl.uniprot.org/citations/23859711http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23859711
http://purl.uniprot.org/citations/23859711http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/23859711
http://purl.uniprot.org/uniprot/#_P14060-mappedCitation-23859711http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23859711
http://purl.uniprot.org/uniprot/#_P63092-mappedCitation-23859711http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23859711
http://purl.uniprot.org/uniprot/#_A0A0C4DFV7-mappedCitation-23859711http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23859711
http://purl.uniprot.org/uniprot/#_A0A0S2Z3S5-mappedCitation-23859711http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23859711
http://purl.uniprot.org/uniprot/#_A0A590UJF0-mappedCitation-23859711http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23859711
▶