| http://purl.uniprot.org/citations/23863939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23863939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23863939 | http://www.w3.org/2000/01/rdf-schema#comment | "Structural analysis of class B G-protein-coupled receptors (GPCRs), cell-surface proteins that respond to peptide hormones, has been restricted to the amino-terminal extracellular domain, thus providing little understanding of the membrane-spanning signal transduction domain. The corticotropin-releasing factor receptor type 1 is a class B receptor which mediates the response to stress and has been considered a drug target for depression and anxiety. Here we report the crystal structure of the transmembrane domain of the human corticotropin-releasing factor receptor type 1 in complex with the small-molecule antagonist CP-376395. The structure provides detailed insight into the architecture of class B receptors. Atomic details of the interactions of the receptor with the non-peptide ligand that binds deep within the receptor are described. This structure provides a model for all class B GPCRs and may aid in the design of new small-molecule drugs for diseases of brain and metabolism."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature12357"xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature12357"xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Dore A.S."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Dore A.S."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Kean J."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Kean J."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Hollenstein K."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Hollenstein K."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Marshall F.H."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Marshall F.H."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Cooke R.M."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Cooke R.M."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Jazayeri A."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Jazayeri A."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Bortolato A."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Bortolato A."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Cheng R.K."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Cheng R.K."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Weir M."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/author | "Weir M."xsd:string |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23863939 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |