| http://purl.uniprot.org/citations/23865080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23865080 | http://www.w3.org/2000/01/rdf-schema#comment | "Asthma susceptibility genes are mapped to a region on human chromosome 5q31-q33, which contains a cluster of proinflammatory cytokine genes such as interleukin-13 (IL-13), which is associated with asthma. This study investigated the allele frequencies of two single nucleotide polymorphisms (SNPs) (-1111C>T and 4257C>A) in the IL-13 gene between asthmatics and healthy volunteers as well as the relationship between these SNPs and IL-13 production. DNA extracted from buffy coat of asthmatic and control subjects was genotyped using the PCR-RFLP method. Amount of IL-13 produced by mitogen-stimulated peripheral blood leucocytes PBLs (PBLs) was determined by ELISA. The frequencies of the -1111C and 4257G wild-type alleles were 0.52 and 0.55 in asthmatics and were 0.67 and 0.56 in controls. A significant (P < 0.05) association was found between genotype and allele frequencies of SNP at position -1111C>T between asthmatic and control groups (OR, 1.810; 95% CI = 1.184 to 2.767; P < 0.05). The mitogen-stimulated PBLs from asthmatics produced higher amounts of IL-13 production (P < 0.001). The 4257GA heterozygous and 4257AA homozygous mutant alleles were associated with higher IL-13 production in asthmatics (P < 0.05). Our results show that the -1111T mutant allele are associated with asthma and the 4257A mutant alleles are associated with elevated IL-13 production."xsd:string |
| http://purl.uniprot.org/citations/23865080 | http://purl.org/dc/terms/identifier | "doi:10.1155/2013/981012"xsd:string |
| http://purl.uniprot.org/citations/23865080 | http://purl.uniprot.org/core/author | "Tan L.K."xsd:string |
| http://purl.uniprot.org/citations/23865080 | http://purl.uniprot.org/core/author | "Radhakrishnan A.K."xsd:string |
| http://purl.uniprot.org/citations/23865080 | http://purl.uniprot.org/core/author | "Liam C.K."xsd:string |
| http://purl.uniprot.org/citations/23865080 | http://purl.uniprot.org/core/author | "Raj V.L."xsd:string |
| http://purl.uniprot.org/citations/23865080 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23865080 | http://purl.uniprot.org/core/name | "Biomed Res Int"xsd:string |
| http://purl.uniprot.org/citations/23865080 | http://purl.uniprot.org/core/pages | "981012"xsd:string |
| http://purl.uniprot.org/citations/23865080 | http://purl.uniprot.org/core/title | "Single nucleotide polymorphism in the promoter of the human interleukin-13 gene is associated with asthma in Malaysian adults."xsd:string |
| http://purl.uniprot.org/citations/23865080 | http://purl.uniprot.org/core/volume | "2013"xsd:string |
| http://purl.uniprot.org/citations/23865080 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23865080 |
| http://purl.uniprot.org/citations/23865080 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23865080 |
| http://purl.uniprot.org/uniprot/#_Q4VB50-mappedCitation-23865080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23865080 |
| http://purl.uniprot.org/uniprot/#_Q4VB51-mappedCitation-23865080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23865080 |
| http://purl.uniprot.org/uniprot/#_Q4VB53-mappedCitation-23865080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23865080 |
| http://purl.uniprot.org/uniprot/#_P35225-mappedCitation-23865080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23865080 |
| http://purl.uniprot.org/uniprot/Q4VB51 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23865080 |
| http://purl.uniprot.org/uniprot/Q4VB53 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23865080 |
| http://purl.uniprot.org/uniprot/P35225 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23865080 |
| http://purl.uniprot.org/uniprot/Q4VB50 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23865080 |