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| http://purl.uniprot.org/citations/23867513 | http://www.w3.org/2000/01/rdf-schema#comment | "The product of a proto-oncogene, the c-Met protein is a transmembrane receptor tyrosine kinase. Its only known ligand, hepatocyte growth factor/scatter factor, regulates cell growth, motility, migration, invasion, proliferation, and angiogenesis. Dysregulation of c-Met and hepatocyte growth factor have been observed in both clear cell and non-clear cell renal cell carcinomas (RCCs), although only papillary RCCs harbor activating mutations in the MET gene. In clear cell RCC, there is evidence of a direct link between loss of von Hippel-Lindau and up-regulation of c-Met. As in other cancers, high expression of c-Met correlates with worse outcomes in RCC. In vitro and in vivo preclinical RCC models demonstrate cancer control with small molecule and antibodies against c-Met. Given these findings, the c-Met pathway is a logical therapeutic target in RCC, and several agents are in clinical testing with early signs of efficacy."xsd:string |
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| http://purl.uniprot.org/citations/23867513 | http://purl.uniprot.org/core/author | "Harshman L.C."xsd:string |
| http://purl.uniprot.org/citations/23867513 | http://purl.uniprot.org/core/author | "Choueiri T.K."xsd:string |
| http://purl.uniprot.org/citations/23867513 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23867513 | http://purl.uniprot.org/core/name | "Cancer J"xsd:string |
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| http://purl.uniprot.org/citations/23867513 | http://purl.uniprot.org/core/title | "Targeting the hepatocyte growth factor/c-Met signaling pathway in renal cell carcinoma."xsd:string |
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