| http://purl.uniprot.org/citations/23871486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23871486 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23871486 | http://www.w3.org/2000/01/rdf-schema#comment | "Nectin and nectin-like proteins are cell adhesion molecules that mediate the formation of cell adherens junctions by forming homo- or heterodimers. Some members of this protein family can also be used by immune receptors to mediate immune recognition. For instance, nectin-like 2 (Necl-2) is used as a ligand for the immune system by interaction with the immune receptor CRTAM (class-I MHC-restricted T cell associated molecule), which is mainly expressed on the surface of cytotoxic lymphocyte cells. However, the Necl-2/CRTAM binding mode and its relationship to cell adhesion are not known. Here, we report a Necl-2/CRTAM complex structure, demonstrating that Necl-2 binding to CRTAM competes with the dimerization of CRTAM and possibly Necl-2. Necl-2 occupies the CRTAM homodimer interface, making homodimerization impossible. Mutational and functional analyses identified key amino acids (double "lock-and-key") responsible for the binding. Our work illustrates how the cell adhesion molecule Necl-2 competitively binds the immune receptor CRTAM."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2013.06.006"xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.str.2013.06.006"xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Gao G.F."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Gao G.F."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Lu G."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Lu G."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Fan Z."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Fan Z."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Qi J."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Qi J."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Zhang Z."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Zhang B."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Zhang B."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Yan J."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/author | "Yan J."xsd:string |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23871486 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |