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| http://purl.uniprot.org/citations/23871667 | http://www.w3.org/2000/01/rdf-schema#comment | "Female human pluripotent stem cells show vast heterogeneity regarding the status of X chromosome inactivation. By comparing the gene expression profile of cells with two active X chromosomes (XaXa cells) to that of cells with only one active X chromosome (XaXi cells), a set of autosomal genes was shown to be overexpressed in the XaXa cells. Among these genes, we found significant enrichment for genes regulated by the X-linked transcription factor ELK-1. Comparison of the phenotype of XaXa and XaXi cells demonstrated differences in programmed cell death and differentiation, implying some growth disadvantage of the XaXa cells. Interestingly, ELK-1-overexpressing cells mimicked the phenotype of XaXa cells, whereas knockdown of ELK-1 with small hairpin RNA mimicked the phenotype of XaXi cells. When cultured at low oxygen levels, these cellular differences were considerably weakened. Our analysis implies a role of ELK-1 in the differences between pluripotent stem cells with distinct X chromosome inactivation statuses."xsd:string |
| http://purl.uniprot.org/citations/23871667 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.celrep.2013.06.026"xsd:string |
| http://purl.uniprot.org/citations/23871667 | http://purl.uniprot.org/core/author | "Benvenisty N."xsd:string |
| http://purl.uniprot.org/citations/23871667 | http://purl.uniprot.org/core/author | "Yanuka O."xsd:string |
| http://purl.uniprot.org/citations/23871667 | http://purl.uniprot.org/core/author | "Bruck T."xsd:string |
| http://purl.uniprot.org/citations/23871667 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23871667 | http://purl.uniprot.org/core/name | "Cell Rep"xsd:string |
| http://purl.uniprot.org/citations/23871667 | http://purl.uniprot.org/core/pages | "262-270"xsd:string |
| http://purl.uniprot.org/citations/23871667 | http://purl.uniprot.org/core/title | "Human pluripotent stem cells with distinct X inactivation status show molecular and cellular differences controlled by the X-Linked ELK-1 gene."xsd:string |
| http://purl.uniprot.org/citations/23871667 | http://purl.uniprot.org/core/volume | "4"xsd:string |
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