| http://purl.uniprot.org/citations/23878072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23878072 | http://www.w3.org/2000/01/rdf-schema#comment | "We sought to investigate the clinicopathological significance and biological function of hepatoma-derived growth factor (HDGF) in Ewing's sarcoma. Our results showed that HDGF expression is up-regulated in Ewing's sarcoma. Nuclear HDGF expression is significantly associated with tumour volume (p < 0.001), metastases at diagnosis (p < 0.001), low overall survival rate (p < 0.001) and low disease-free survival rate (p < 0.001). HDGF knock-down results in significant reduction of Ewing's sarcoma cell growth, proliferation and enhances tumourigenesis, both in vitro and in vivo. Meanwhile, HDGF knock-down causes cell cycle arrest and enhanced sensitization to serum starvation-induced apoptosis. Furthermore, recombinant HDGF promotes proliferation and colony formation of Ewing's sarcoma cells. Ninety-eight candidate HDGF downstream genes were identified in Ewing's sarcoma cells using cDNA microarray analysis. In addition, we found that HDGF knock-down inhibited FLI1 expression in Ewing's sarcoma cells at the mRNA and protein levels. Our findings suggest that HDGF exhibits oncogenic properties and may be a novel prognostic factor in Ewing's sarcoma. Targeting HDGF might be a potential therapeutic strategy for Ewing's sarcoma."xsd:string |
| http://purl.uniprot.org/citations/23878072 | http://purl.org/dc/terms/identifier | "doi:10.1002/path.4241"xsd:string |
| http://purl.uniprot.org/citations/23878072 | http://purl.uniprot.org/core/author | "Li H."xsd:string |
| http://purl.uniprot.org/citations/23878072 | http://purl.uniprot.org/core/author | "Liang Y."xsd:string |
| http://purl.uniprot.org/citations/23878072 | http://purl.uniprot.org/core/author | "Kang L."xsd:string |
| http://purl.uniprot.org/citations/23878072 | http://purl.uniprot.org/core/author | "Shi H."xsd:string |
| http://purl.uniprot.org/citations/23878072 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/23878072 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/23878072 | http://purl.uniprot.org/core/author | "Yang Y."xsd:string |
| http://purl.uniprot.org/citations/23878072 | http://purl.uniprot.org/core/author | "Han A."xsd:string |
| http://purl.uniprot.org/citations/23878072 | http://purl.uniprot.org/core/author | "Dai S."xsd:string |
| http://purl.uniprot.org/citations/23878072 | http://purl.uniprot.org/core/author | "Zhen T."xsd:string |
| http://purl.uniprot.org/citations/23878072 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23878072 | http://purl.uniprot.org/core/name | "J Pathol"xsd:string |
| http://purl.uniprot.org/citations/23878072 | http://purl.uniprot.org/core/pages | "323-334"xsd:string |
| http://purl.uniprot.org/citations/23878072 | http://purl.uniprot.org/core/title | "Clinical and biological significance of hepatoma-derived growth factor in Ewing's sarcoma."xsd:string |
| http://purl.uniprot.org/citations/23878072 | http://purl.uniprot.org/core/volume | "231"xsd:string |
| http://purl.uniprot.org/citations/23878072 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23878072 |
| http://purl.uniprot.org/citations/23878072 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23878072 |
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| http://purl.uniprot.org/uniprot/#_A8K8G0-mappedCitation-23878072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23878072 |
| http://purl.uniprot.org/uniprot/#_B7Z958-mappedCitation-23878072 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23878072 |