| http://purl.uniprot.org/citations/23880533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23880533 | http://www.w3.org/2000/01/rdf-schema#comment | "Genomic loci composed of more than one gene are frequently subjected to differential gene expression, with the chicken α-globin domain being a clear example. In the present study we aim to understand the globin switching mechanisms responsible for the epigenetic silencing of the embryonic π gene and the transcriptional activation of the adult α(D) and α(A) genes at the genomic domain level. In early stages, we describe a physical contact between the embryonic π gene and the distal 3' enhancer that is lost later during development. We show that such a level of regulation is achieved through the establishment of a DNA hypermethylation sub-domain that includes the embryonic gene and the adjacent genomic sequences. The multifunctional CCCTCC-binding factor (CTCF), which is located upstream of the α(D) gene promoter, delimits this sub-domain and creates a transition between the inactive sub-domain and the active sub-domain, which includes the adult α(D) gene. In avian-transformed erythroblast HD3 cells that are induced to differentiate, we found active DNA demethylation of the adult α(D) promoter, coincident with the incorporation of 5-hydroxymethylcytosine (5hmC) and concomitant with adult gene transcriptional activation. These results suggest that autonomous silencing of the embryonic π gene is needed to facilitate an optimal topological conformation of the domain. This model proposes that CTCF is contributing to a specific chromatin configuration that is necessary for differential α-globin gene expression during development."xsd:string |
| http://purl.uniprot.org/citations/23880533 | http://purl.org/dc/terms/identifier | "doi:10.4161/epi.25472"xsd:string |
| http://purl.uniprot.org/citations/23880533 | http://purl.uniprot.org/core/author | "Recillas-Targa F."xsd:string |
| http://purl.uniprot.org/citations/23880533 | http://purl.uniprot.org/core/author | "Guerrero G."xsd:string |
| http://purl.uniprot.org/citations/23880533 | http://purl.uniprot.org/core/author | "Valdes-Quezada C."xsd:string |
| http://purl.uniprot.org/citations/23880533 | http://purl.uniprot.org/core/author | "Arriaga-Canon C."xsd:string |
| http://purl.uniprot.org/citations/23880533 | http://purl.uniprot.org/core/author | "Fonseca-Guzman Y."xsd:string |
| http://purl.uniprot.org/citations/23880533 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23880533 | http://purl.uniprot.org/core/name | "Epigenetics"xsd:string |
| http://purl.uniprot.org/citations/23880533 | http://purl.uniprot.org/core/pages | "827-838"xsd:string |
| http://purl.uniprot.org/citations/23880533 | http://purl.uniprot.org/core/title | "CTCF demarcates chicken embryonic alpha-globin gene autonomous silencing and contributes to adult stage-specific gene expression."xsd:string |
| http://purl.uniprot.org/citations/23880533 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/23880533 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23880533 |
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