| http://purl.uniprot.org/citations/23884954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23884954 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendritic spines are a major substrate of brain plasticity. Although many studies have focused on Ca(2+)/calmodulin-dependent protein kinase II (CaMKII)-mediated regulation of spine dynamics and synaptic function in adult brain, much less is know about protein kinase A (PKA)-dependent regulation of spine shape dynamics during postnatal brain development. Synaptopodin is a dendritic spine associated modulator of actin dynamics and a substrate of PKA. Here we show that NMDA and cAMP-induced dendritic spine expansion is impaired in hippocampal slices from 15- and 21-d-old synaptopodin-deficient mice. We further show that synaptopodin is required for full expression of PKA-dependent hippocampal long-term potentiation in 15- and 21-d-old, but not adult, mice. PKA-induced cAMP response element-binding phosphorylation is normal in the hippocampus of synaptopodin-deficient mice, suggesting that synaptopodin functions independently of cAMP response element-binding. Our results identify synaptopodin as a substrate of PKA in hippocampal neurons and point to an essential role for synaptopodin in activity-dependent regulation of dendritic spine dynamics and synaptic plasticity in postnatal brain development."xsd:string |
| http://purl.uniprot.org/citations/23884954 | http://purl.org/dc/terms/identifier | "doi:10.1523/jneurosci.2983-12.2013"xsd:string |
| http://purl.uniprot.org/citations/23884954 | http://purl.uniprot.org/core/author | "Faul C."xsd:string |
| http://purl.uniprot.org/citations/23884954 | http://purl.uniprot.org/core/author | "Mundel P."xsd:string |
| http://purl.uniprot.org/citations/23884954 | http://purl.uniprot.org/core/author | "Zhang X.L."xsd:string |
| http://purl.uniprot.org/citations/23884954 | http://purl.uniprot.org/core/author | "Stanton P.K."xsd:string |
| http://purl.uniprot.org/citations/23884954 | http://purl.uniprot.org/core/author | "Upreti C."xsd:string |
| http://purl.uniprot.org/citations/23884954 | http://purl.uniprot.org/core/author | "Poschel B."xsd:string |
| http://purl.uniprot.org/citations/23884954 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23884954 | http://purl.uniprot.org/core/name | "J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/23884954 | http://purl.uniprot.org/core/pages | "12510-12518"xsd:string |
| http://purl.uniprot.org/citations/23884954 | http://purl.uniprot.org/core/title | "Essential role for synaptopodin in dendritic spine plasticity of the developing hippocampus."xsd:string |
| http://purl.uniprot.org/citations/23884954 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/23884954 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23884954 |
| http://purl.uniprot.org/citations/23884954 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23884954 |
| http://purl.uniprot.org/uniprot/#_E0CYK1-mappedCitation-23884954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23884954 |
| http://purl.uniprot.org/uniprot/#_E9Q3E2-mappedCitation-23884954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23884954 |
| http://purl.uniprot.org/uniprot/#_Q3TY32-mappedCitation-23884954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23884954 |
| http://purl.uniprot.org/uniprot/#_Q3TBE2-mappedCitation-23884954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23884954 |
| http://purl.uniprot.org/uniprot/#_Q3U336-mappedCitation-23884954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23884954 |
| http://purl.uniprot.org/uniprot/#_Q497V1-mappedCitation-23884954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23884954 |
| http://purl.uniprot.org/uniprot/#_Q3TA13-mappedCitation-23884954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23884954 |
| http://purl.uniprot.org/uniprot/#_Q8CC35-mappedCitation-23884954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23884954 |
| http://purl.uniprot.org/uniprot/#_Q3URF1-mappedCitation-23884954 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23884954 |