| http://purl.uniprot.org/citations/23885123 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23885123 | http://www.w3.org/2000/01/rdf-schema#comment | "Intestinal barrier function is regulated by epithelial tight junctions (TJs), structures that control paracellular permeability. Junctional adhesion molecule-A (JAM-A) is a TJ-associated protein that regulates barrier; however, mechanisms linking JAM-A to epithelial permeability are poorly understood. Here we report that JAM-A associates directly with ZO-2 and indirectly with afadin, and this complex, along with PDZ-GEF1, activates the small GTPase Rap2c. Supporting a functional link, small interfering RNA-mediated down-regulation of the foregoing regulatory proteins results in enhanced permeability similar to that observed after JAM-A loss. JAM-A-deficient mice and cultured epithelial cells demonstrate enhanced paracellular permeability to large molecules, revealing a potential role of JAM-A in controlling perijunctional actin cytoskeleton in addition to its previously reported role in regulating claudin proteins and small-molecule permeability. Further experiments suggest that JAM-A does not regulate actin turnover but modulates activity of RhoA and phosphorylation of nonmuscle myosin, both implicated in actomyosin contraction. These results suggest that JAM-A regulates epithelial permeability via association with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and control contraction of the apical cytoskeleton."xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.org/dc/terms/identifier | "doi:10.1091/mbc.e13-06-0298"xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/author | "Stehle T."xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/author | "Dermody T.S."xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/author | "Hall R.A."xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/author | "Schaefer S.A."xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/author | "Leoni G."xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/author | "Nusrat A."xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/author | "Parkos C.A."xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/author | "Sumagin R."xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/author | "Rankin C.R."xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/author | "Monteiro A.C."xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/author | "Reiter D.M."xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/author | "Mina M.J."xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/name | "Mol Biol Cell"xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/pages | "2849-2860"xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/title | "JAM-A associates with ZO-2, afadin, and PDZ-GEF1 to activate Rap2c and regulate epithelial barrier function."xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/23885123 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23885123 |
| http://purl.uniprot.org/citations/23885123 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23885123 |
| http://purl.uniprot.org/uniprot/P55196#attribution-6C97B353FBE385BF5F0587C5DDB83D31 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23885123 |
| http://purl.uniprot.org/uniprot/P55196#attribution-C155CF6B8B692FC225C3BB0FADAD8E92 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23885123 |
| http://purl.uniprot.org/uniprot/Q9Y624#attribution-39922025953C65457269AC4EFBFD341E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23885123 |