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http://purl.uniprot.org/citations/23886189http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23886189http://www.w3.org/2000/01/rdf-schema#comment"

Background

Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide. The outcome of HCC depends mainly on its early diagnosis. To date, the performance of traditional biomarkers is unsatisfactory. Talins were firstly identified as cytoplasmic protein partners of integrins but Talin-1 appears to play a crucial role in cancer formation and progression. Our study was conducted to assess the diagnostic value of serum Talin-1 (TLN1) compared to the most feasible traditional biomarker alpha-fetoprotein (AFP) for the diagnosis of HCC.

Methods

TLN1 was detected using enzyme linked immunosorbent assay (ELISA) in serum samples from 120 Egyptian subjects including 40 with HCC, 40 with liver cirrhosis (LC) and 40 healthy controls (HC).

Results

ROC curve analysis was used to create a predictive model for TLN1 relative to AFP in HCC diagnosis. Serum levels of TLN1 in hepatocellular carcinoma patients were significantly higher compared to the other groups (p<0.0001). The diagnostic accuracy of TLN1 was higher than that of AFP regarding sensitivity, specificity, positive predictive value and negative predictive value in diagnosis of HCC.

Conclusions

The present study showed for the first time that Talin-1 (TLN1) is a potential diagnostic marker for HCC, with a higher sensitivity and specificity compared to the traditional biomarker AFP."xsd:string
http://purl.uniprot.org/citations/23886189http://purl.org/dc/terms/identifier"doi:10.7314/apjcp.2013.14.6.3819"xsd:string
http://purl.uniprot.org/citations/23886189http://purl.uniprot.org/core/author"Abdel Wahab A.H."xsd:string
http://purl.uniprot.org/citations/23886189http://purl.uniprot.org/core/author"Attia M.S."xsd:string
http://purl.uniprot.org/citations/23886189http://purl.uniprot.org/core/author"Hassan Z.A."xsd:string
http://purl.uniprot.org/citations/23886189http://purl.uniprot.org/core/author"Youns M.M."xsd:string
http://purl.uniprot.org/citations/23886189http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23886189http://purl.uniprot.org/core/name"Asian Pac J Cancer Prev"xsd:string
http://purl.uniprot.org/citations/23886189http://purl.uniprot.org/core/pages"3819-3823"xsd:string
http://purl.uniprot.org/citations/23886189http://purl.uniprot.org/core/title"Serum talin-1 is a potential novel biomarker for diagnosis of hepatocellular carcinoma in Egyptian patients."xsd:string
http://purl.uniprot.org/citations/23886189http://purl.uniprot.org/core/volume"14"xsd:string
http://purl.uniprot.org/citations/23886189http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23886189
http://purl.uniprot.org/citations/23886189http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/23886189
http://purl.uniprot.org/uniprot/#_Q9H3E8-mappedCitation-23886189http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23886189
http://purl.uniprot.org/uniprot/#_Q9Y490-mappedCitation-23886189http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/23886189
http://purl.uniprot.org/uniprot/Q9Y490http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/23886189
http://purl.uniprot.org/uniprot/Q9H3E8http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/23886189