| http://purl.uniprot.org/citations/23886940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23886940 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23886940 | http://www.w3.org/2000/01/rdf-schema#comment | "Notch signaling is a conserved signaling pathway implicated in embryogenesis and adult tissue maintenance. Notch signaling strength is strictly regulated, notably by maintaining a controlled pool of functional receptor at the cell surface. Mammalian non-activated Notch receptor is internalized, ubiquitylated by the Itch E3 ubiquitin ligase and degraded in the lysosomes. Here, we show that β-arrestins are necessary for Itch-Notch interaction and for Itch-driven ubiquitylation and degradation of Notch. Interestingly, β-arrestins do not directly bind Itch but heterodimerize with a member of another subfamily of arrestins called ARRDC1 or α-arrestin 1, which harbors PPxY motifs that allow direct interaction with Itch. Cells transfected with ARRDC1 mutated in PPxY motifs show reduced Itch-mediated Notch ubiquitylation and impaired lysosomal degradation of Notch, as observed in β-arrestin(-/-) or Itch(-/-) cells. Our data show for the first time that ARRDC1 and β-arrestins heterodimerize and cooperate in the same complex to promote non-activated Notch receptor degradation, thus acting as negative regulators of Notch signaling."xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.130500"xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.130500"xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/author | "Israel A."xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/author | "Israel A."xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/author | "Meas-Yedid V."xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/author | "Meas-Yedid V."xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/author | "Brou C."xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/author | "Brou C."xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/author | "Chastagner P."xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/author | "Chastagner P."xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/author | "Puca L."xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/author | "Puca L."xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/name | "J. Cell Sci."xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/pages | "4457-4468"xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/pages | "4457-4468"xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/title | "Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals."xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/title | "Alpha-arrestin 1 (ARRDC1) and beta-arrestins cooperate to mediate Notch degradation in mammals."xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/volume | "126"xsd:string |
| http://purl.uniprot.org/citations/23886940 | http://purl.uniprot.org/core/volume | "126"xsd:string |