| http://purl.uniprot.org/citations/23901104 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23901104 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23901104 | http://www.w3.org/2000/01/rdf-schema#comment | "The multisubunit homotypic fusion and vacuole protein sorting (HOPS) membrane-tethering complex is required for late endosome-lysosome and autophagosome-lysosome fusion in mammals. We have determined the crystal structure of the human HOPS subunit Vps33A, confirming its identity as a Sec1/Munc18 family member. We show that HOPS subunit Vps16 recruits Vps33A to the human HOPS complex and that residues 642-736 are necessary and sufficient for this interaction, and we present the crystal structure of Vps33A in complex with Vps16(642-736). Mutations at the binding interface disrupt the Vps33A-Vps16 interaction both in vitro and in cells, preventing recruitment of Vps33A to the HOPS complex. The Vps33A-Vps16 complex provides a structural framework for studying the association between Sec1/Munc18 proteins and tethering complexes."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1307074110"xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1307074110"xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/author | "Graham S.C."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/author | "Graham S.C."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/author | "Deane J.E."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/author | "Deane J.E."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/author | "Luzio J.P."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/author | "Luzio J.P."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/author | "Owen D.J."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/author | "Owen D.J."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/author | "Gray S.R."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/author | "Gray S.R."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/author | "Wartosch L."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/author | "Wartosch L."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/author | "Scourfield E.J."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/author | "Scourfield E.J."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/pages | "13345-13350"xsd:string |
| http://purl.uniprot.org/citations/23901104 | http://purl.uniprot.org/core/pages | "13345-13350"xsd:string |