| http://purl.uniprot.org/citations/23904441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23904441 | http://www.w3.org/2000/01/rdf-schema#comment | "A growing body of evidence suggests an essential role of the heterodimeric cytokine, IL-27, for regulating immunity. IL-27 is composed of two subunits (p28 and EBI3) and is classified as a member of the IL-12 family of cytokines. APCs have been recognized as a major cellular source of IL-27 following activation with microbial products or IFNs (types I and II). In this review, we describe the current knowledge of the implications of IL-27 during the pathogenesis of infectious and autoimmune diseases. Experimental studies have used genetically targeted IL-27RA-/- mice, EBI3-/- mice, and p28-/-mice or involved study designs with administration of bioengineered IL-27/IL-27RA homologs. Whereas many reports have described that IL-27 suppresses inflammation, we also review the current literature, suggesting promotion of inflammation by IL-27 in some settings. Recent advances have also been made in understanding the cross-talk of cleavage products of the complement system with IL-27-mediated immune responses. Additional data on IL-27 have been obtained recently by observational studies in human patients with acute and chronic inflammatory diseases. Collectively, the findings from the past decade identify IL-27 as a critical immunoregulatory cytokine, especially for T cells, whereas some controversy is fueled by results challenging the view of IL-27 as a classical silencer of inflammation."xsd:string |
| http://purl.uniprot.org/citations/23904441 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.0213107"xsd:string |
| http://purl.uniprot.org/citations/23904441 | http://purl.uniprot.org/core/author | "Ward P.A."xsd:string |
| http://purl.uniprot.org/citations/23904441 | http://purl.uniprot.org/core/author | "Bosmann M."xsd:string |
| http://purl.uniprot.org/citations/23904441 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23904441 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/23904441 | http://purl.uniprot.org/core/pages | "1159-1165"xsd:string |
| http://purl.uniprot.org/citations/23904441 | http://purl.uniprot.org/core/title | "Modulation of inflammation by interleukin-27."xsd:string |
| http://purl.uniprot.org/citations/23904441 | http://purl.uniprot.org/core/volume | "94"xsd:string |
| http://purl.uniprot.org/citations/23904441 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23904441 |
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