| http://purl.uniprot.org/citations/23906792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23906792 | http://www.w3.org/2000/01/rdf-schema#comment | "Connective tissue growth factor (CTGF) plays an important role in lung fibrosis. In this study, we investigated the role of Rac1, mixed-lineage kinase 3 (MLK3), c-Jun N-terminal kinase (JNK), and activator protein-1 (AP-1) in CTGF-induced collagen I expression in human lung fibroblasts. CTGF caused concentration- and time-dependent increases in collagen I expression. CTGF-induced collagen I expression was inhibited by the dominant negative mutant (DN) of Rac1 (RacN17), MLK3DN, MLK3 inhibitor (K252a), JNK1DN, JNK2DN, a JNK inhibitor (SP600125), and an AP-1 inhibitor (curcumin). Treatment of cells with CTGF caused activation of Rac1, MLK3, JNK, and AP-1. The CTGF-induced increase in MLK3 phosphorylation was inhibited by RacN17. Treatment with RacN17 and the MLK3DN inhibited CTGF-induced JNK phosphorylation. CTGF caused increases in c-Jun phosphorylation and the recruitment of c-Jun and c-Fos to the collagen I promoter. Furthermore, stimulation of cells with the CTGF resulted in increases in AP-1-luciferase activity; this effect was inhibited by Rac1N17, MLK3DN, JNK1DN, and JNK2DN. Moreover, CTGF-induced α-smooth muscle actin (α-SMA) expression was inhibited by the procollagen I small interfering RNA (siRNA). These results suggest for the first time that CTGF acting through Rac1 activates the MLK3/JNK signaling pathway, which in turn initiates AP-1 activation and recruitment of c-Jun and c-Fos to the collagen I promoter and ultimately induces collagen I expression in human lung fibroblasts."xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbamcr.2013.07.016"xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://purl.uniprot.org/core/author | "Chen B.C."xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://purl.uniprot.org/core/author | "Lin C.H."xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://purl.uniprot.org/core/author | "Hong C.Y."xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://purl.uniprot.org/core/author | "Chen T.T."xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://purl.uniprot.org/core/author | "Yu M.C."xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://purl.uniprot.org/core/author | "Yu C.C."xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://purl.uniprot.org/core/author | "Tsai Y.J."xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://purl.uniprot.org/core/author | "Chien M.H."xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://purl.uniprot.org/core/author | "Bai K.J."xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://purl.uniprot.org/core/author | "Tung W.H."xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://purl.uniprot.org/core/author | "Weng C.M."xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23906792 | http://purl.uniprot.org/core/name | "Biochim Biophys Acta"xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://purl.uniprot.org/core/pages | "2823-2833"xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://purl.uniprot.org/core/title | "Connective tissue growth factor induces collagen I expression in human lung fibroblasts through the Rac1/MLK3/JNK/AP-1 pathway."xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://purl.uniprot.org/core/volume | "1833"xsd:string |
| http://purl.uniprot.org/citations/23906792 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23906792 |
| http://purl.uniprot.org/citations/23906792 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23906792 |
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| http://purl.uniprot.org/uniprot/#_B7Z4S2-mappedCitation-23906792 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23906792 |