| http://purl.uniprot.org/citations/23909438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23909438 | http://www.w3.org/2000/01/rdf-schema#comment | "Nogo-A is the largest isoform of the Nogo/RTN4 (reticulon 4) proteins and has been characterized as a major myelin-associated inhibitor of regenerative nerve growth in the adult CNS (central nervous system). Apart from the myelin sheath, Nogo-A is expressed at high levels in principal neurons of the CNS. The specificity of Nogo-A resides in its central domain, NiG. We identified Apg-1, a member of the stress-induced Hsp110 (heat-shock protein of 110 kDa) family, as a novel interactor of NiG/Nogo-A. The interaction is selective because Apg-1 interacts with Nogo-A/RTN4-A, but not with RTN1-A, the closest paralogue of Nogo-A. Conversely, Nogo-A binds to Apg-1, but not to Apg-2 or Hsp105, two other members of the Hsp110 family. We characterized the Nogo-A-Apg-1 interaction by affinity precipitation, co-immunoprecipitation and proximity ligation assay, using primary hippocampal neurons derived from Nogo-deficient mice. Under conditions of hypoxic and oxidative stress we found that Nogo-A and Apg-1 were tightly co-regulated in hippocampal neurons. Although both proteins were up-regulated under hypoxic conditions, their expression levels were reduced upon the addition of hydrogen peroxide. Taken together, we suggest that Nogo-A is closely involved in the neuronal response to hypoxic and oxidative stress, an observation that may be of relevance not only in stroke-induced ischaemia, but also in neuroblastoma formation."xsd:string |
| http://purl.uniprot.org/citations/23909438 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20130579"xsd:string |
| http://purl.uniprot.org/citations/23909438 | http://purl.uniprot.org/core/author | "Hess D."xsd:string |
| http://purl.uniprot.org/citations/23909438 | http://purl.uniprot.org/core/author | "Lindner H."xsd:string |
| http://purl.uniprot.org/citations/23909438 | http://purl.uniprot.org/core/author | "Sarg B."xsd:string |
| http://purl.uniprot.org/citations/23909438 | http://purl.uniprot.org/core/author | "Kern F."xsd:string |
| http://purl.uniprot.org/citations/23909438 | http://purl.uniprot.org/core/author | "Obermair G.J."xsd:string |
| http://purl.uniprot.org/citations/23909438 | http://purl.uniprot.org/core/author | "Hengst L."xsd:string |
| http://purl.uniprot.org/citations/23909438 | http://purl.uniprot.org/core/author | "Offterdinger M."xsd:string |
| http://purl.uniprot.org/citations/23909438 | http://purl.uniprot.org/core/author | "Bandtlow C.E."xsd:string |
| http://purl.uniprot.org/citations/23909438 | http://purl.uniprot.org/core/author | "Schweigreiter R."xsd:string |
| http://purl.uniprot.org/citations/23909438 | http://purl.uniprot.org/core/author | "Stanika R.I."xsd:string |
| http://purl.uniprot.org/citations/23909438 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23909438 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/23909438 | http://purl.uniprot.org/core/pages | "217-227"xsd:string |
| http://purl.uniprot.org/citations/23909438 | http://purl.uniprot.org/core/title | "Nogo-A couples with Apg-1 through interaction and co-ordinate expression under hypoxic and oxidative stress."xsd:string |
| http://purl.uniprot.org/citations/23909438 | http://purl.uniprot.org/core/volume | "455"xsd:string |
| http://purl.uniprot.org/citations/23909438 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23909438 |
| http://purl.uniprot.org/citations/23909438 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23909438 |
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| http://purl.uniprot.org/uniprot/#_E0CY23-mappedCitation-23909438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23909438 |
| http://purl.uniprot.org/uniprot/#_A0A8I6GLD1-mappedCitation-23909438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23909438 |
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| http://purl.uniprot.org/uniprot/#_A0A8L2UHV9-mappedCitation-23909438 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23909438 |