| http://purl.uniprot.org/citations/23910378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23910378 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23910378 | http://www.w3.org/2000/01/rdf-schema#comment | "Binding of dsDNA by cyclic GMP-AMP (cGAMP) synthase (cGAS) triggers formation of the metazoan second messenger c[G(2',5')pA(3',5')p], which binds the signaling protein STING with subsequent activation of the interferon (IFN) pathway. We show that human hSTING(H232) adopts a "closed" conformation upon binding c[G(2',5')pA(3',5')p] and its linkage isomer c[G(2',5')pA(2',5')p], as does mouse mSting(R231) on binding c[G(2',5')pA(3',5')p], c[G(3',5')pA(3',5')p] and the antiviral agent DMXAA, leading to similar "closed" conformations. Comparing hSTING to mSting, 2',5'-linkage-containing cGAMP isomers were more specific triggers of the IFN pathway compared to the all-3',5'-linkage isomer. Guided by structural information, we identified a unique point mutation (S162A) placed within the cyclic-dinucleotide-binding site of hSTING that rendered it sensitive to the otherwise mouse-specific drug DMXAA, a conclusion validated by binding studies. Our structural and functional analysis highlights the unexpected versatility of STING in the recognition of natural and synthetic ligands within a small-molecule pocket created by the dimerization of STING."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.07.023"xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.07.023"xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Dai P."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Dai P."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Shuman S."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Shuman S."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Patel D.J."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Patel D.J."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Tuschl T."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Tuschl T."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Deng L."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Deng L."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Serganov A.A."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Serganov A.A."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Jones R.A."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Jones R.A."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Gao P."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Gao P."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Ascano M."xsd:string |
| http://purl.uniprot.org/citations/23910378 | http://purl.uniprot.org/core/author | "Ascano M."xsd:string |