| http://purl.uniprot.org/citations/23910567 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23910567 | http://www.w3.org/2000/01/rdf-schema#comment | "The replication factor Cdc45 has essential functions in the initiation and elongation steps of eukaryotic DNA replication and plays an important role in the intra-S-phase checkpoint. Its interactions with other replication proteins during the cell cycle and after intra-S-phase checkpoint activation are only partially characterized. In the present study, we show that the C terminal part of Cdc45 may mediate its interactions with Claspin. The interactions of human Cdc45 with the three replication factors Claspin, replication protein A and DNA polymerase δ are maximal during the S phase. Following UVC-induced DNA damage, Cdc45-Claspin complex formation is reduced, whereas the binding of Cdc45 to replication protein A is not affected. We also show that treatment of cells with UCN-01 and phosphatidylinositol 3-kinase-like kinase inhibitors does not rescue the UV-induced destabilization of Cdc45-Claspin interactions, suggesting that the loss of the interaction between Cdc45 and Claspin occurs upstream of ataxia telangiectasia and Rad 3-related activation in the intra-S-phase checkpoint."xsd:string |
| http://purl.uniprot.org/citations/23910567 | http://purl.org/dc/terms/identifier | "doi:10.1111/febs.12465"xsd:string |
| http://purl.uniprot.org/citations/23910567 | http://purl.uniprot.org/core/author | "Santocanale C."xsd:string |
| http://purl.uniprot.org/citations/23910567 | http://purl.uniprot.org/core/author | "Broderick R."xsd:string |
| http://purl.uniprot.org/citations/23910567 | http://purl.uniprot.org/core/author | "Rainey M.D."xsd:string |
| http://purl.uniprot.org/citations/23910567 | http://purl.uniprot.org/core/author | "Nasheuer H.P."xsd:string |
| http://purl.uniprot.org/citations/23910567 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23910567 | http://purl.uniprot.org/core/name | "FEBS J"xsd:string |
| http://purl.uniprot.org/citations/23910567 | http://purl.uniprot.org/core/pages | "4888-4902"xsd:string |
| http://purl.uniprot.org/citations/23910567 | http://purl.uniprot.org/core/title | "Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage."xsd:string |
| http://purl.uniprot.org/citations/23910567 | http://purl.uniprot.org/core/volume | "280"xsd:string |
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