| http://purl.uniprot.org/citations/23911328 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23911328 | http://www.w3.org/2000/01/rdf-schema#comment | "The risk of specific cancers increases in patients with metabolic dysfunction, including obesity and diabetes. Here, we use Drosophila as a model to explore the effects of diet on tumor progression. Feeding Drosophila a diet high in carbohydrates was previously demonstrated to direct metabolic dysfunction, including hyperglycemia, hyperinsulinemia, and insulin resistance. We demonstrate that high dietary sugar also converts Ras/Src-transformed tissue from localized growths to aggressive tumors with emergent metastases. Whereas most tissues displayed insulin resistance, Ras/Src tumors retained insulin pathway sensitivity, increased the ability to import glucose, and resisted apoptosis. High dietary sugar increased canonical Wingless/Wnt pathway activity, which upregulated insulin receptor gene expression to promote insulin sensitivity. The result is a feed-forward circuit that amplified diet-mediated malignant phenotypes within Ras/Src-transformed tumors. By targeting multiple steps in this circuit with rationally applied drug combinations, we demonstrate the potential of combinatorial drug intervention to treat diet-enhanced malignant tumors."xsd:string |
| http://purl.uniprot.org/citations/23911328 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.06.030"xsd:string |
| http://purl.uniprot.org/citations/23911328 | http://purl.uniprot.org/core/author | "Hirabayashi S."xsd:string |
| http://purl.uniprot.org/citations/23911328 | http://purl.uniprot.org/core/author | "Cagan R.L."xsd:string |
| http://purl.uniprot.org/citations/23911328 | http://purl.uniprot.org/core/author | "Baranski T.J."xsd:string |
| http://purl.uniprot.org/citations/23911328 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23911328 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/23911328 | http://purl.uniprot.org/core/pages | "664-675"xsd:string |
| http://purl.uniprot.org/citations/23911328 | http://purl.uniprot.org/core/title | "Transformed Drosophila cells evade diet-mediated insulin resistance through wingless signaling."xsd:string |
| http://purl.uniprot.org/citations/23911328 | http://purl.uniprot.org/core/volume | "154"xsd:string |
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