| http://purl.uniprot.org/citations/23913414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23913414 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA sequences capable of forming triplexes are prevalent in the human genome and have been found to be intrinsically mutagenic. Consequently, a balance between DNA repair and apoptosis is critical to counteract their effect on genomic integrity. Using triplex-forming oligonucleotides to synthetically create altered helical distortions, we have determined that pro-apoptotic pathways are activated by the formation of triplex structures. Moreover, the TFIIH factor, XPD, occupies a central role in triggering apoptosis in response to triplex-induced DNA strand breaks. Here, we show that triplexes are capable of inducing XPD-independent double strand breaks, which result in the formation of γH2AX foci. XPD was subsequently recruited to the triplex-induced double strand breaks and co-localized with γH2AX at the damage site. Furthermore, phosphorylation of H2AX tyrosine 142 was found to stimulate the signaling pathway of XPD-dependent apoptosis. We suggest that this mechanism may play an active role in minimizing genomic instability induced by naturally occurring noncanonical structures, perhaps protecting against cancer initiation."xsd:string |
| http://purl.uniprot.org/citations/23913414 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkt670"xsd:string |
| http://purl.uniprot.org/citations/23913414 | http://purl.uniprot.org/core/author | "Rogers F.A."xsd:string |
| http://purl.uniprot.org/citations/23913414 | http://purl.uniprot.org/core/author | "Kaushik Tiwari M."xsd:string |
| http://purl.uniprot.org/citations/23913414 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23913414 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/23913414 | http://purl.uniprot.org/core/pages | "8979-8994"xsd:string |
| http://purl.uniprot.org/citations/23913414 | http://purl.uniprot.org/core/title | "XPD-dependent activation of apoptosis in response to triplex-induced DNA damage."xsd:string |
| http://purl.uniprot.org/citations/23913414 | http://purl.uniprot.org/core/volume | "41"xsd:string |
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