| http://purl.uniprot.org/citations/23913921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23913921 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23913921 | http://www.w3.org/2000/01/rdf-schema#comment | "The Piwi-piRNA (PIWI-interacting RNA) complex (Piwi-piRISC) in Drosophila ovarian somatic cells represses transposons transcriptionally to maintain genome integrity; however, the underlying mechanisms remain obscure. Here, we reveal that DmGTSF1, a Drosophila homolog of gametocyte-specific factor 1 (GTSF1) (which is required for transposon silencing in mouse testes), is necessary for Piwi-piRISC to repress target transposons and neighboring genes. DmGTSF1 depletion affected neither piRNA biogenesis nor nuclear import of Piwi-piRISC. DmGTSF1 mutations caused derepression of transposons and loss of ovary follicle layers, resulting in female infertility. We suggest that DmGTSF1, a nuclear Piwi interactor, is an integral factor in Piwi-piRISC-mediated transcriptional silencing."xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.221515.113"xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.221515.113"xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/author | "Saito K."xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/author | "Saito K."xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/author | "Iwasaki Y.W."xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/author | "Iwasaki Y.W."xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/author | "Siomi H."xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/author | "Siomi H."xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/author | "Siomi M.C."xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/author | "Siomi M.C."xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/author | "Shibuya A."xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/author | "Shibuya A."xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/author | "Ohtani H."xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/author | "Ohtani H."xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/pages | "1656-1661"xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/pages | "1656-1661"xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/title | "DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila ovary."xsd:string |
| http://purl.uniprot.org/citations/23913921 | http://purl.uniprot.org/core/title | "DmGTSF1 is necessary for Piwi-piRISC-mediated transcriptional transposon silencing in the Drosophila ovary."xsd:string |