| http://purl.uniprot.org/citations/23918927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23918927 | http://www.w3.org/2000/01/rdf-schema#comment | "The C-type lectin macrophage galactose-type lectin (MGL) exerts an immunosuppressive role reflected by its interaction with terminal GalNAc moieties, such as the Tn antigen, on CD45 of effector T cells, thereby down-regulating T cell receptor signaling, cytokine responses, and induction of T cell death. Here, we provide evidence for the pathways that control the specific expression of GalNAc moieties on human CD4(+) T cells. GalNAc epitopes were readily detectable on the cell surface after T cell activation and required de novo protein synthesis. Expression of GalNAc-containing MGL ligands was completely dependent on PKC and did not involve NF-κB. Instead, activation of the downstream ERK MAPK pathway led to decreased mRNA levels and activity of the core 1 β3GalT enzyme and its chaperone Cosmc, favoring the expression of Tn antigen. In conclusion, expression of GalNAc moieties mirrors the T cell activation status, and thus only highly stimulated T cells are prone to the suppressive action of MGL."xsd:string |
| http://purl.uniprot.org/citations/23918927 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m113.471045"xsd:string |
| http://purl.uniprot.org/citations/23918927 | http://purl.uniprot.org/core/author | "van Kooyk Y."xsd:string |
| http://purl.uniprot.org/citations/23918927 | http://purl.uniprot.org/core/author | "van Vliet S.J."xsd:string |
| http://purl.uniprot.org/citations/23918927 | http://purl.uniprot.org/core/author | "Tefsen B."xsd:string |
| http://purl.uniprot.org/citations/23918927 | http://purl.uniprot.org/core/author | "Garcia-Vallejo J.J."xsd:string |
| http://purl.uniprot.org/citations/23918927 | http://purl.uniprot.org/core/author | "Kalay H."xsd:string |
| http://purl.uniprot.org/citations/23918927 | http://purl.uniprot.org/core/author | "Lenos K."xsd:string |
| http://purl.uniprot.org/citations/23918927 | http://purl.uniprot.org/core/author | "Vuist I.M."xsd:string |
| http://purl.uniprot.org/citations/23918927 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23918927 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/23918927 | http://purl.uniprot.org/core/pages | "27519-27532"xsd:string |
| http://purl.uniprot.org/citations/23918927 | http://purl.uniprot.org/core/title | "Human T cell activation results in extracellular signal-regulated kinase (ERK)-calcineurin-dependent exposure of Tn antigen on the cell surface and binding of the macrophage galactose-type lectin (MGL)."xsd:string |
| http://purl.uniprot.org/citations/23918927 | http://purl.uniprot.org/core/volume | "288"xsd:string |
| http://purl.uniprot.org/citations/23918927 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23918927 |
| http://purl.uniprot.org/citations/23918927 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23918927 |
| http://purl.uniprot.org/uniprot/#_A8K7G0-mappedCitation-23918927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23918927 |
| http://purl.uniprot.org/uniprot/#_J3KR22-mappedCitation-23918927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23918927 |
| http://purl.uniprot.org/uniprot/#_Q8IUN9-mappedCitation-23918927 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23918927 |
| http://purl.uniprot.org/uniprot/Q8IUN9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23918927 |
| http://purl.uniprot.org/uniprot/A8K7G0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23918927 |
| http://purl.uniprot.org/uniprot/J3KR22 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/23918927 |