| http://purl.uniprot.org/citations/23918937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23918937 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23918937 | http://www.w3.org/2000/01/rdf-schema#comment | "Katanin is an evolutionarily conserved microtubule (MT)-severing complex implicated in multiple aspects of MT dynamics. In Caenorhabditis elegans, the katanin homologue MEI-1 is required for meiosis, but must be inactivated before mitosis. Here we show that PPFR-1, a regulatory subunit of a trimeric protein phosphatase 4 complex, enhanced katanin MT-severing activity during C. elegans meiosis. Loss of ppfr-1, similarly to the inactivation of MT severing, caused a specific defect in meiosis II spindle disassembly. We show that a fraction of PPFR-1 was degraded after meiosis, contributing to katanin inactivation. PPFR-1 interacted with MEL-26, the substrate recognition subunit of the CUL-3 RING E3 ligase (CRL3(MEL-26)), which also targeted MEI-1 for post-meiotic degradation. Reversible protein phosphorylation of MEI-1 may ensure temporal activation of the katanin complex during meiosis, whereas CRL3(MEL-26)-mediated degradation of both MEI-1 and its activator PPFR-1 ensure efficient katanin inactivation in the transition to mitosis."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201304174"xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.201304174"xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/author | "Formstecher E."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/author | "Formstecher E."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/author | "Boulin T."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/author | "Boulin T."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/author | "Dumont J."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/author | "Dumont J."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/author | "Pintard L."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/author | "Pintard L."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/author | "Richaudeau B."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/author | "Richaudeau B."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/author | "Mains P.E."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/author | "Mains P.E."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/author | "Gomes J.E."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/author | "Gomes J.E."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/author | "Tavernier N."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/author | "Tavernier N."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/23918937 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |