| http://purl.uniprot.org/citations/23921125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23921125 | http://www.w3.org/2000/01/rdf-schema#comment | "Hippocampal development is coordinated by both extracellular factors like GABA neurotransmission and intracellular components like DISC1. We previously reported that SLC12A2-dependent GABA depolarization and DISC1 coregulate hippocampal neuronal development, and 2 SNPs in these genes linked to mRNA expression interactively increase schizophrenia risk. Using functional MRI, we now confirm this biological interaction in vivo by showing in 2 independent samples of healthy individuals (total N = 349) that subjects homozygous for both risk alleles evince dramatically decreased hippocampal area activation (Cohen's d = 0.78)and connectivity (d = 0.57) during a recognition memory task. These data highlight the importance of epistatic models in understanding genetic association with complex brain phenotypes."xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://purl.org/dc/terms/identifier | "doi:10.1172/jci67510"xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://purl.uniprot.org/core/author | "Chen Q."xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://purl.uniprot.org/core/author | "Song H."xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://purl.uniprot.org/core/author | "Lu B."xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://purl.uniprot.org/core/author | "Ming G.L."xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://purl.uniprot.org/core/author | "Weinberger D.R."xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://purl.uniprot.org/core/author | "Callicott J.H."xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://purl.uniprot.org/core/author | "Mattay V.S."xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://purl.uniprot.org/core/author | "Berman K.F."xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://purl.uniprot.org/core/author | "White M.G."xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://purl.uniprot.org/core/author | "Baranger D.A."xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://purl.uniprot.org/core/author | "Feighery E.L."xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23921125 | http://purl.uniprot.org/core/name | "J Clin Invest"xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://purl.uniprot.org/core/pages | "2961-2964"xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://purl.uniprot.org/core/title | "DISC1 and SLC12A2 interaction affects human hippocampal function and connectivity."xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/23921125 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23921125 |
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| http://purl.uniprot.org/uniprot/#_P55011-mappedCitation-23921125 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23921125 |