| http://purl.uniprot.org/citations/23921530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23921530 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23921530 | http://www.w3.org/2000/01/rdf-schema#comment | "Upon receptor activation, the myeloid C-type lectin receptor Mincle signals via the Syk-CARD9-Bcl10-MALT1 pathway. It does so by recruiting the ITAM-bearing FcεRI-γ. The related receptor macrophage C-type Lectin (MCL) has also been shown to be associated with Syk and to be dependent upon this signaling axis. We have previously shown that MCL co-precipitates with FcεRI-γ, but were unable to show a direct association, suggesting that MCL associates with FcεRI-γ via another molecule. Here, we have used rat primary cells and cell lines to investigate this missing link. A combination of flow cytometric and biochemical analysis showed that Mincle and MCL form heteromers on the cell surface. Furthermore, association with MCL and FcεRI-γ increased Mincle expression and enhanced phagocytosis of Ab-coated beads. The results presented in this paper suggest that the Mincle/MCL/FcεRI-γ complex is the functionally optimal form for these C-type lectin receptors on the surface of myeloid cells."xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201343752"xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.201343752"xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/author | "Fossum S."xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/author | "Fossum S."xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/author | "Dissen E."xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/author | "Dissen E."xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/author | "Daws M.R."xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/author | "Daws M.R."xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/author | "Lobato-Pascual A."xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/author | "Lobato-Pascual A."xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/author | "Saether P.C."xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/author | "Saether P.C."xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/name | "Eur. J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/name | "Eur. J. Immunol."xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/pages | "3167-3174"xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/pages | "3167-3174"xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/title | "Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and FcepsilonRI-gamma."xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/title | "Mincle, the receptor for mycobacterial cord factor, forms a functional receptor complex with MCL and FcepsilonRI-gamma."xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/volume | "43"xsd:string |
| http://purl.uniprot.org/citations/23921530 | http://purl.uniprot.org/core/volume | "43"xsd:string |