| http://purl.uniprot.org/citations/23921640 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23921640 | http://www.w3.org/2000/01/rdf-schema#comment | "Transcription of tRNA-encoding genes by RNA polymerase (Pol) III requires the six-subunit general transcription factor IIIC that uses subcomplexes τA and τB to recognize two gene-internal promoter elements named A- and B-box. The Schizosaccharomyces pombe τA subcomplex comprises subunits Sfc1, Sfc4 and Sfc7. The crystal structure of the Sfc1/Sfc7 heterodimer reveals similar domains and overall domain architecture to the Pol II-specific general transcription factor TFIIF Rap30/Rap74. The N-terminal Sfc1/Sfc7 dimerization module consists of a triple β-barrel similar to the N-terminal TFIIF Rap30/Rap74 dimerization module, whereas the C-terminal Sfc1 DNA-binding domain contains a winged-helix domain most similar to the TFIIF Rap30 C-terminal winged-helix domain. Sfc1 DNA-binding domain recognizes single and double-stranded DNA by an unknown mechanism. Several features observed for A-box recognition by τA resemble the recognition of promoters by bacterial RNA polymerase, where σ factor unfolds double-stranded DNA and stabilizes the non-coding DNA strand in an open conformation. Such a function has also been proposed for TFIIF, suggesting that the observed structural similarity between Sfc1/Sfc7 and TFIIF Rap30/Rap74 might also reflect similar functions."xsd:string |
| http://purl.uniprot.org/citations/23921640 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkt664"xsd:string |
| http://purl.uniprot.org/citations/23921640 | http://purl.uniprot.org/core/author | "Baudin F."xsd:string |
| http://purl.uniprot.org/citations/23921640 | http://purl.uniprot.org/core/author | "Muller C.W."xsd:string |
| http://purl.uniprot.org/citations/23921640 | http://purl.uniprot.org/core/author | "Taylor N.M."xsd:string |
| http://purl.uniprot.org/citations/23921640 | http://purl.uniprot.org/core/author | "von Scheven G."xsd:string |
| http://purl.uniprot.org/citations/23921640 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23921640 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/23921640 | http://purl.uniprot.org/core/pages | "9183-9196"xsd:string |
| http://purl.uniprot.org/citations/23921640 | http://purl.uniprot.org/core/title | "RNA polymerase III-specific general transcription factor IIIC contains a heterodimer resembling TFIIF Rap30/Rap74."xsd:string |
| http://purl.uniprot.org/citations/23921640 | http://purl.uniprot.org/core/volume | "41"xsd:string |
| http://purl.uniprot.org/citations/23921640 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23921640 |
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