| http://purl.uniprot.org/citations/23922195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23922195 | http://www.w3.org/2000/01/rdf-schema#comment | "The aim of this study was to summarize results on the association of cytotoxic T-lymphocyte antigen-4 (CTLA-4) promoter exon-1 +49 and 1722T/C polymorphism with systemic lupus erythematosus (SLE) susceptibility by using the meta-analysis. We searched all the publications about the association between CTLA-4) promoter exon-1 +49 and 1722T/C polymorphism and SLE from PubMed, Elsevier Science Direct, Chinese Biomedical Literature Database (CBM), Chinese National Knowledge Infrastructure (CNKI), and Wanfang (Chinese). Previous CTLA-4 association studies with SLE, however, have produced inconsistent results. We have performed a meta-analysis to better assess the purported associations. A total of 17 independent studies (to June 2012) testing association between one or more CTLA-4 polymorphisms and SLE were used in this analysis. We have compared allele and genotype frequencies at two polymorphic sites found in exon-1 (at +49) and the promoter region (at -1722). The data demonstrate that the exon-1 +49 polymorphism is associated with SLE susceptibility in Asian population. The overall risk, measured by odds ratio (OR), stratification by ethnicity indicates the exon-1 +49 GG+GA genotype is associated with SLE, at least in Asians (OR = 0.85, 95 % CI = 0.73-0.99, P = 0.04 for GG+GA vs. AA; OR = 0.85, 95 % CI = 0.72-1.00, P = 0.05 for AG vs. AA). Similar trends are found in allele-specific risk estimates and disease association. Overall, there was significant association between the 1722T/C polymorphism and overall SLE risks (OR = 0.78, 95 % CI = 0.63-0.97, P = 0.04 for GG+GA vs. AA, OR = 0.87, 95 % CI = 0.76-0.99, P = 0.04 for G vs. A) in Asian population.In summary, this meta-analysis demonstrates that the CTLA-4 promoter +49A/G and promoter -1722C/T polymorphism may confer susceptibility to SLE, especially in Asian-derived population."xsd:string |
| http://purl.uniprot.org/citations/23922195 | http://purl.org/dc/terms/identifier | "doi:10.1007/s11033-012-2125-7"xsd:string |
| http://purl.uniprot.org/citations/23922195 | http://purl.uniprot.org/core/author | "Liu T."xsd:string |
| http://purl.uniprot.org/citations/23922195 | http://purl.uniprot.org/core/author | "Ye D."xsd:string |
| http://purl.uniprot.org/citations/23922195 | http://purl.uniprot.org/core/author | "Wang H.Y."xsd:string |
| http://purl.uniprot.org/citations/23922195 | http://purl.uniprot.org/core/author | "Zhang Z.X."xsd:string |
| http://purl.uniprot.org/citations/23922195 | http://purl.uniprot.org/core/author | "Ren Z."xsd:string |
| http://purl.uniprot.org/citations/23922195 | http://purl.uniprot.org/core/author | "Fan W.J."xsd:string |
| http://purl.uniprot.org/citations/23922195 | http://purl.uniprot.org/core/author | "Zhai J.X."xsd:string |
| http://purl.uniprot.org/citations/23922195 | http://purl.uniprot.org/core/author | "Zou L.W."xsd:string |
| http://purl.uniprot.org/citations/23922195 | http://purl.uniprot.org/core/author | "Dai R.X."xsd:string |
| http://purl.uniprot.org/citations/23922195 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23922195 | http://purl.uniprot.org/core/name | "Mol Biol Rep"xsd:string |
| http://purl.uniprot.org/citations/23922195 | http://purl.uniprot.org/core/pages | "5213-5223"xsd:string |
| http://purl.uniprot.org/citations/23922195 | http://purl.uniprot.org/core/title | "CTLA-4 polymorphisms and systemic lupus erythematosus (SLE): a meta-analysis."xsd:string |
| http://purl.uniprot.org/citations/23922195 | http://purl.uniprot.org/core/volume | "40"xsd:string |
| http://purl.uniprot.org/citations/23922195 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23922195 |
| http://purl.uniprot.org/citations/23922195 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23922195 |
| http://purl.uniprot.org/uniprot/#_E9L3G1-mappedCitation-23922195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23922195 |
| http://purl.uniprot.org/uniprot/#_E9L3G3-mappedCitation-23922195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23922195 |
| http://purl.uniprot.org/uniprot/#_E9L3G0-mappedCitation-23922195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23922195 |
| http://purl.uniprot.org/uniprot/#_Q0Q5F0-mappedCitation-23922195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23922195 |
| http://purl.uniprot.org/uniprot/#_Q0Q5F1-mappedCitation-23922195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23922195 |
| http://purl.uniprot.org/uniprot/#_P16410-mappedCitation-23922195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23922195 |