| http://purl.uniprot.org/citations/23926132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23926132 | http://www.w3.org/2000/01/rdf-schema#comment | "Post-oral sugar actions enhance the intake of and preference for sugar-rich foods, a process referred to as appetition. Here, we investigated the role of intestinal sodium glucose cotransporters (SGLTs) in sugar appetition in C57BL/6J mice using sugars and nonmetabolizable sugar analogs that differ in their affinity for SGLT1 and SGLT3. In experiments 1 and 2, food-restricted mice were trained (1 h/day) to consume a flavored saccharin solution [conditioned stimulus (CS-)] paired with intragastric (IG) self-infusions of water and a different flavored solution (CS+) paired with infusions of 8 or 12% sugars (glucose, fructose, and galactose) or sugar analogs (α-methyl-D-glucopyranoside, MDG; 3-O-methyl-D-glucopyranoside, OMG). Subsequent two-bottle CS+ vs. CS-choice tests were conducted without coinfusions. Infusions of the SGLT1 ligands glucose, galactose, MDG, and OMG stimulated CS+ licking above CS-levels. However, only glucose, MDG, and galactose conditioned significant CS+ preferences, with the SGLT3 ligands (glucose, MDG) producing the strongest preferences. Fructose, which is not a ligand for SGLTs, failed to stimulate CS+ intake or preference. Experiment 3 revealed that IG infusion of MDG+phloridzin (an SGLT1/3 antagonist) blocked MDG appetition, whereas phloridzin had minimal effects on glucose-induced appetition. However, adding phloretin (a GLUT2 antagonist) to the glucose+phloridzin infusion blocked glucose appetition. Taken together, these findings suggest that humoral signals generated by intestinal SGLT1 and SGLT3, and to a lesser degree, GLUT2, mediate post-oral sugar appetition in mice. The MDG results indicate that sugar metabolism is not essential for the post-oral intake-stimulating and preference-conditioning actions of sugars in mice."xsd:string |
| http://purl.uniprot.org/citations/23926132 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpregu.00297.2013"xsd:string |
| http://purl.uniprot.org/citations/23926132 | http://purl.uniprot.org/core/author | "Sclafani A."xsd:string |
| http://purl.uniprot.org/citations/23926132 | http://purl.uniprot.org/core/author | "Zukerman S."xsd:string |
| http://purl.uniprot.org/citations/23926132 | http://purl.uniprot.org/core/author | "Ackroff K."xsd:string |
| http://purl.uniprot.org/citations/23926132 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23926132 | http://purl.uniprot.org/core/name | "Am J Physiol Regul Integr Comp Physiol"xsd:string |
| http://purl.uniprot.org/citations/23926132 | http://purl.uniprot.org/core/pages | "R840-53"xsd:string |
| http://purl.uniprot.org/citations/23926132 | http://purl.uniprot.org/core/title | "Post-oral appetite stimulation by sugars and nonmetabolizable sugar analogs."xsd:string |
| http://purl.uniprot.org/citations/23926132 | http://purl.uniprot.org/core/volume | "305"xsd:string |
| http://purl.uniprot.org/citations/23926132 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23926132 |
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