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http://purl.uniprot.org/citations/23930970http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Aims

Inflammatory markers play an important role in the development of diseases related to metabolic syndrome, such as type 2 diabetes (T2D) and coronary artery disease (CAD). The present study evaluates the association of -2518A>G polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene with T2D and CAD.

Results

The frequency of the G allele is greater in CAD cases (35%) as compared to T2D (24.6%) and controls (31%), while the frequency of the A allele is higher in T2D cases (75.4%) as compared to CAD cases (65%) and controls (69%). The analysis has revealed that in comparison to T2D cases, the G allele increases the risk of CAD by 1.9-fold (p=0.008; odds ratio [OR]=1.9, 1.18-3.06 at 95% confidence interval [CI]) but in comparison to controls the G-allele provided protection against T2D (p=0.011; OR=0.55, 0.35-0.87 at 95% CI), both under the dominant model (AG+GG vs. AA).

Conclusion

Results of the present study suggests that G-allele of MCP-1 -2518A>G polymorphism is associated with reduced risk of T2D and increased risk of CAD in the population of Punjab. The results indicate that there is a difference in the association of risk alleles with phenotypes of metabolic syndrome. Body mass index and waist circumference are important risk factors for T2D in the population of Punjab."xsd:string
http://purl.uniprot.org/citations/23930970http://purl.org/dc/terms/identifier"doi:10.1089/gtmb.2013.0227"xsd:string
http://purl.uniprot.org/citations/23930970http://purl.uniprot.org/core/author"Arora P."xsd:string
http://purl.uniprot.org/citations/23930970http://purl.uniprot.org/core/author"Kaur R."xsd:string
http://purl.uniprot.org/citations/23930970http://purl.uniprot.org/core/author"Bhanwer A.J."xsd:string
http://purl.uniprot.org/citations/23930970http://purl.uniprot.org/core/author"Matharoo K."xsd:string
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http://purl.uniprot.org/citations/23930970http://purl.uniprot.org/core/name"Genet Test Mol Biomarkers"xsd:string
http://purl.uniprot.org/citations/23930970http://purl.uniprot.org/core/pages"750-755"xsd:string
http://purl.uniprot.org/citations/23930970http://purl.uniprot.org/core/title"Association of -2518A>G promoter polymorphism in the monocyte chemoattractant protein-1 (MCP-1) gene with type 2 diabetes and coronary artery disease."xsd:string
http://purl.uniprot.org/citations/23930970http://purl.uniprot.org/core/volume"17"xsd:string
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