| http://purl.uniprot.org/citations/23933751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23933751 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23933751 | http://www.w3.org/2000/01/rdf-schema#comment | "Compelling evidence indicates that two autosomal recessive Parkinson's disease genes, PINK1 (PARK6) and Parkin (PARK2), cooperate to mediate the autophagic clearance of damaged mitochondria (mitophagy). Mutations in the F-box domain-containing protein Fbxo7 (encoded by PARK15) also cause early-onset autosomal recessive Parkinson's disease, by an unknown mechanism. Here we show that Fbxo7 participates in mitochondrial maintenance through direct interaction with PINK1 and Parkin and acts in Parkin-mediated mitophagy. Cells with reduced Fbxo7 expression showed deficiencies in translocation of Parkin to mitochondria, ubiquitination of mitofusin 1 and mitophagy. In Drosophila, ectopic overexpression of Fbxo7 rescued loss of Parkin, supporting a functional relationship between the two proteins. Parkinson's disease-causing mutations in Fbxo7 interfered with this process, emphasizing the importance of mitochondrial dysfunction in Parkinson's disease pathogenesis."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.3489"xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.org/dc/terms/identifier | "doi:10.1038/nn.3489"xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Hardy J."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Hardy J."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Houlden H."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Houlden H."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Laman H."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Laman H."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Wood N.W."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Wood N.W."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Nelson D.E."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Nelson D.E."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Abramov A.Y."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Abramov A.Y."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Lewis P.A."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Lewis P.A."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Whitworth A.J."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Whitworth A.J."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Wray S."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Wray S."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Sanchez-Martinez A."xsd:string |
| http://purl.uniprot.org/citations/23933751 | http://purl.uniprot.org/core/author | "Sanchez-Martinez A."xsd:string |