| http://purl.uniprot.org/citations/23935187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23935187 | http://www.w3.org/2000/01/rdf-schema#comment | "LEC-1 is a major galectin in Caenorhabditis elegans and contains two carbohydrate recognition domains (CRDs), N-CRD and C-CRD. To determine the role of LEC-1, we examined the phenotypes of a mutant C. elegans strain lacking lec-1. We observed negligible differences in embryogenesis, morphogenesis and egg laying at 20 °C between the mutant and the wild-type. Furthermore, the life spans of the mutant and the wild-type were equivalent at either 20 °C or 25 °C. However, the lec-1 mutant showed a greater susceptibility to H2O2 and paraquat than the wild-type. This result suggests an increased susceptibility to oxidative stress, with the phenotypes being similar to those of lec-10 deletion mutants as previously described. To understand the molecular mechanism underlying this phenotype, C. elegans proteins bound by either the LEC-1 N-CRD or C-CRD were isolated and identified using a nano liquid chromatography-tandem mass spectrometry technique. MIG-6 was identified as a major binding partner of LEC-1 with both N- and C-CRD. From these results and previous reports, we speculate that interaction of LEC-1 and MIG-6 in the pharynx may affect susceptibility to paraquat and that LEC-10 has different functions from LEC-1 in regulating H2O2 and paraquat resistance in the intestine."xsd:string |
| http://purl.uniprot.org/citations/23935187 | http://purl.org/dc/terms/identifier | "doi:10.1093/jb/mvt074"xsd:string |
| http://purl.uniprot.org/citations/23935187 | http://purl.uniprot.org/core/author | "Sugiura K."xsd:string |
| http://purl.uniprot.org/citations/23935187 | http://purl.uniprot.org/core/author | "Takeuchi T."xsd:string |
| http://purl.uniprot.org/citations/23935187 | http://purl.uniprot.org/core/author | "Kasai K."xsd:string |
| http://purl.uniprot.org/citations/23935187 | http://purl.uniprot.org/core/author | "Arata Y."xsd:string |
| http://purl.uniprot.org/citations/23935187 | http://purl.uniprot.org/core/author | "Nemoto-Sasaki Y."xsd:string |
| http://purl.uniprot.org/citations/23935187 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23935187 | http://purl.uniprot.org/core/name | "J Biochem"xsd:string |
| http://purl.uniprot.org/citations/23935187 | http://purl.uniprot.org/core/pages | "455-464"xsd:string |
| http://purl.uniprot.org/citations/23935187 | http://purl.uniprot.org/core/title | "Galectin LEC-1 plays a defensive role against damage due to oxidative stress in Caenorhabditis elegans."xsd:string |
| http://purl.uniprot.org/citations/23935187 | http://purl.uniprot.org/core/volume | "154"xsd:string |
| http://purl.uniprot.org/citations/23935187 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23935187 |
| http://purl.uniprot.org/citations/23935187 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23935187 |
| http://purl.uniprot.org/uniprot/#_A0A5S9MMA9-mappedCitation-23935187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23935187 |
| http://purl.uniprot.org/uniprot/#_A0A5S9MMB0-mappedCitation-23935187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23935187 |
| http://purl.uniprot.org/uniprot/#_A0A5S9MMI0-mappedCitation-23935187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23935187 |
| http://purl.uniprot.org/uniprot/#_A0A5S9MMS0-mappedCitation-23935187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23935187 |
| http://purl.uniprot.org/uniprot/#_A0A5S9MNG3-mappedCitation-23935187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23935187 |
| http://purl.uniprot.org/uniprot/#_A0A5S9MNN4-mappedCitation-23935187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23935187 |
| http://purl.uniprot.org/uniprot/#_A0A5S9MPU7-mappedCitation-23935187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23935187 |
| http://purl.uniprot.org/uniprot/#_A0A5S9MQJ1-mappedCitation-23935187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23935187 |
| http://purl.uniprot.org/uniprot/#_A0A5S9MRP0-mappedCitation-23935187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23935187 |
| http://purl.uniprot.org/uniprot/#_A0A679L8M9-mappedCitation-23935187 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23935187 |