| http://purl.uniprot.org/citations/23938298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23938298 | http://www.w3.org/2000/01/rdf-schema#comment | "Topoisomerase IIβ (Top2β)-DNA cleavage complexes are known to arrest elongating RNA polymerase II (RNAPII), triggering a proteasomal degradation of the RNAPII large subunit (RNAPII LS) and Top2β itself as a prelude to DNA repair. Here, we demonstrate that the degradation of Top2β occurs through a novel ubiquitin-independent mechanism that requires only 19S AAA ATPases and 20S proteasome. Our results suggest that 19S AAA ATPases play a dual role in sensing the Top2β cleavage complex and coordinating its degradation by 20S proteasome when RNAPII is persistently stalled by the Top2β protein roadblock. Clarification of this transcription-associated proteasome pathway could shed light on a general role of 19S AAA ATPases in processing tight protein-DNA complexes during transcription elongation."xsd:string |
| http://purl.uniprot.org/citations/23938298 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.00403-13"xsd:string |
| http://purl.uniprot.org/citations/23938298 | http://purl.uniprot.org/core/author | "Ban Y."xsd:string |
| http://purl.uniprot.org/citations/23938298 | http://purl.uniprot.org/core/author | "Liu L.F."xsd:string |
| http://purl.uniprot.org/citations/23938298 | http://purl.uniprot.org/core/author | "Ho C.W."xsd:string |
| http://purl.uniprot.org/citations/23938298 | http://purl.uniprot.org/core/author | "Lyu Y.L."xsd:string |
| http://purl.uniprot.org/citations/23938298 | http://purl.uniprot.org/core/author | "Lin R.K."xsd:string |
| http://purl.uniprot.org/citations/23938298 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23938298 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/23938298 | http://purl.uniprot.org/core/pages | "4008-4016"xsd:string |
| http://purl.uniprot.org/citations/23938298 | http://purl.uniprot.org/core/title | "Activation of a novel ubiquitin-independent proteasome pathway when RNA polymerase II encounters a protein roadblock."xsd:string |
| http://purl.uniprot.org/citations/23938298 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/23938298 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23938298 |
| http://purl.uniprot.org/citations/23938298 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23938298 |
| http://purl.uniprot.org/uniprot/#_B4DKD0-mappedCitation-23938298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23938298 |
| http://purl.uniprot.org/uniprot/#_B4DLV2-mappedCitation-23938298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23938298 |
| http://purl.uniprot.org/uniprot/#_F6U5K2-mappedCitation-23938298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23938298 |
| http://purl.uniprot.org/uniprot/#_F6XX57-mappedCitation-23938298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23938298 |
| http://purl.uniprot.org/uniprot/#_B7ZB27-mappedCitation-23938298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23938298 |
| http://purl.uniprot.org/uniprot/#_Q64511-mappedCitation-23938298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23938298 |
| http://purl.uniprot.org/uniprot/#_L8E8K5-mappedCitation-23938298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23938298 |
| http://purl.uniprot.org/uniprot/#_Q02880-mappedCitation-23938298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23938298 |
| http://purl.uniprot.org/uniprot/#_Q3TR62-mappedCitation-23938298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23938298 |
| http://purl.uniprot.org/uniprot/#_Q59H80-mappedCitation-23938298 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23938298 |