| http://purl.uniprot.org/citations/23939750 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23939750 | http://www.w3.org/2000/01/rdf-schema#comment | "Astrocytes express two sodium-coupled transporters, glutamate-aspartate transporter (GLAST) and glutamate transporter-1 (GLT-1), which are essential for the maintenance of low extracellular glutamate levels. We performed a comparative analysis of the laminar and subcellular expression profile of GLAST and GLT-1 in the developing postnatal mouse hippocampus by using immunohistochemistry and western blotting and employing high-resolution fluorescence microscopy. Astrocytes were identified by costaining with glial fibrillary acidic protein (GFAP) or S100β. In CA1, the density of GFAP-positive cells and GFAP expression rose during the first 2 weeks after birth, paralleled by a steady increase in GLAST immunoreactivity and protein content. Upregulation of GLT-1 was completed only at postnatal days (P) P20-25 and was thus delayed by about 10 days. GLAST staining was highest along the stratum pyramidale and was especially prominent in astrocytes at P3-5. GLAST immunoreactivity indicated no preferential localization to a specific cellular compartment. GLT-1 exhibited a laminar expression pattern from P10-15 on, with the highest immunoreactivity in the stratum lacunosum-moleculare. At the cellular level, GLT-1 immunoreactivity did not entirely cover astrocyte somata and exhibited clusters at processes. In neonatal and juvenile animals, discrete clusters of GLT-1 were also detected at perivascular endfeet. From these results, we conclude there is a remarkable subcellular heterogeneity of GLAST and GLT-1 expression in the developing hippocampus. The clustering of GLT-1 at astrocyte endfeet indicates that it might serve a specialized functional role at the blood-brain barrier during formation of the hippocampal network."xsd:string |
| http://purl.uniprot.org/citations/23939750 | http://purl.org/dc/terms/identifier | "doi:10.1002/cne.23450"xsd:string |
| http://purl.uniprot.org/citations/23939750 | http://purl.uniprot.org/core/author | "Tanaka K."xsd:string |
| http://purl.uniprot.org/citations/23939750 | http://purl.uniprot.org/core/author | "Aida T."xsd:string |
| http://purl.uniprot.org/citations/23939750 | http://purl.uniprot.org/core/author | "Ruther U."xsd:string |
| http://purl.uniprot.org/citations/23939750 | http://purl.uniprot.org/core/author | "Kafitz K.W."xsd:string |
| http://purl.uniprot.org/citations/23939750 | http://purl.uniprot.org/core/author | "Rose C.R."xsd:string |
| http://purl.uniprot.org/citations/23939750 | http://purl.uniprot.org/core/author | "Durry S."xsd:string |
| http://purl.uniprot.org/citations/23939750 | http://purl.uniprot.org/core/author | "Schreiner A.E."xsd:string |
| http://purl.uniprot.org/citations/23939750 | http://purl.uniprot.org/core/author | "Stock M.C."xsd:string |
| http://purl.uniprot.org/citations/23939750 | http://purl.uniprot.org/core/date | "2014"xsd:gYear |
| http://purl.uniprot.org/citations/23939750 | http://purl.uniprot.org/core/name | "J Comp Neurol"xsd:string |
| http://purl.uniprot.org/citations/23939750 | http://purl.uniprot.org/core/pages | "204-224"xsd:string |
| http://purl.uniprot.org/citations/23939750 | http://purl.uniprot.org/core/title | "Laminar and subcellular heterogeneity of GLAST and GLT-1 immunoreactivity in the developing postnatal mouse hippocampus."xsd:string |
| http://purl.uniprot.org/citations/23939750 | http://purl.uniprot.org/core/volume | "522"xsd:string |
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