| http://purl.uniprot.org/citations/23940355 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23940355 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendritic spines are the primary sites of excitatory synaptic transmission in the vertebrate brain, and the morphology of these actin-rich structures correlates with synaptic function. Here we demonstrate a unique method for inducing spine enlargement and synaptic potentiation in dispersed hippocampal neurons, and use this technique to identify a coordinator of these processes; Ras-specific guanine nucleotide releasing factor 2 (RasGRF2). RasGRF2 is a dual Ras/Rac guanine nucleotide exchange factor (GEF) that is known to be necessary for long-term potentiation in situ. Contrary to the prevailing assumption, we find RasGRF2's Rac-GEF activity to be essential for synaptic potentiation by using a molecular replacement strategy designed to dissociate Rac-from Ras-GEF activities. Furthermore, we demonstrate that Rac1 activity itself is sufficient to rapidly modulate postsynaptic strength by using a photoactivatable derivative of this small GTPase. Because Rac1 is a major actin regulator, our results support a model where the initial phase of long-term potentiation is driven by the cytoskeleton."xsd:string |
| http://purl.uniprot.org/citations/23940355 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1304340110"xsd:string |
| http://purl.uniprot.org/citations/23940355 | http://purl.uniprot.org/core/author | "Schwechter B."xsd:string |
| http://purl.uniprot.org/citations/23940355 | http://purl.uniprot.org/core/author | "Tolias K.F."xsd:string |
| http://purl.uniprot.org/citations/23940355 | http://purl.uniprot.org/core/author | "Rosenmund C."xsd:string |
| http://purl.uniprot.org/citations/23940355 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23940355 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/23940355 | http://purl.uniprot.org/core/pages | "14462-14467"xsd:string |
| http://purl.uniprot.org/citations/23940355 | http://purl.uniprot.org/core/title | "RasGRF2 Rac-GEF activity couples NMDA receptor calcium flux to enhanced synaptic transmission."xsd:string |
| http://purl.uniprot.org/citations/23940355 | http://purl.uniprot.org/core/volume | "110"xsd:string |
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