| http://purl.uniprot.org/citations/23943651 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23943651 | http://www.w3.org/2000/01/rdf-schema#comment | "Previously, we detected B cells expressing receptors for blood group A carbohydrates in the CD11b(+)CD5(+) B-1a subpopulation in mice, similar to that in blood group O or B in humans. In the present study, we demonstrate that CD1d-restricted natural killer T (NKT) cells are required to produce anti-A antibodies (Abs), probably through collaboration with B-1a cells. After immunization of wild-type (WT) mice with human blood group A red blood cells (A-RBCs), interleukin (IL)-5 exclusively and transiently increased and the anti-A Abs were elevated in sera. However, these reactions were not observed in CD1d(-/-) mice, which lack NKT cells. Administration of anti-mouse CD1d blocking monoclonal Abs (mAb) prior to immunization abolished IL-5 production by NKT cells and anti-A Ab production in WT mice. Administration of anti-IL-5 neutralizing mAb also diminished anti-A Ab production in WT mice, suggesting that IL-5 secreted from NKT cells critically regulates anti-A Ab production by B-1a cells. In nonobese diabetic/severe combined immunodeficient (NOD/SCID/γc(null)) mice, into which peripheral blood mononuclear cells from type O human volunteers were engrafted, administration of anti-human CD1d mAb prior to A-RBC immunization completely inhibited anti-A Ab production. Thus, anti-CD1d treatment might constitute a novel approach that could help in evading Ab-mediated rejection in ABO-incompatible transplant recipients."xsd:string |
| http://purl.uniprot.org/citations/23943651 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2012-02-407452"xsd:string |
| http://purl.uniprot.org/citations/23943651 | http://purl.uniprot.org/core/author | "Igarashi Y."xsd:string |
| http://purl.uniprot.org/citations/23943651 | http://purl.uniprot.org/core/author | "Tanaka Y."xsd:string |
| http://purl.uniprot.org/citations/23943651 | http://purl.uniprot.org/core/author | "Tashiro H."xsd:string |
| http://purl.uniprot.org/citations/23943651 | http://purl.uniprot.org/core/author | "Tazawa H."xsd:string |
| http://purl.uniprot.org/citations/23943651 | http://purl.uniprot.org/core/author | "Ohdan H."xsd:string |
| http://purl.uniprot.org/citations/23943651 | http://purl.uniprot.org/core/author | "Irei T."xsd:string |
| http://purl.uniprot.org/citations/23943651 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23943651 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/23943651 | http://purl.uniprot.org/core/pages | "2582-2590"xsd:string |
| http://purl.uniprot.org/citations/23943651 | http://purl.uniprot.org/core/title | "Blockade of invariant TCR-CD1d interaction specifically inhibits antibody production against blood group A carbohydrates."xsd:string |
| http://purl.uniprot.org/citations/23943651 | http://purl.uniprot.org/core/volume | "122"xsd:string |
| http://purl.uniprot.org/citations/23943651 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23943651 |
| http://purl.uniprot.org/citations/23943651 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23943651 |
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