| http://purl.uniprot.org/citations/23948300 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23948300 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23948300 | http://www.w3.org/2000/01/rdf-schema#comment | "Among the cytokines linked to inflammation-associated cancer, interleukin (IL)-6 drives many of the cancer "hallmarks" through downstream activation of the gp130/STAT3 signaling pathway. However, we show that the related cytokine IL-11 has a stronger correlation with elevated STAT3 activation in human gastrointestinal cancers. Using genetic mouse models, we reveal that IL-11 has a more prominent role compared to IL-6 during the progression of sporadic and inflammation-associated colon and gastric cancers. Accordingly, in these models and in human tumor cell line xenograft models, pharmacologic inhibition of IL-11 signaling alleviated STAT3 activation, suppressed tumor cell proliferation, and reduced the invasive capacity and growth of tumors. Our results identify IL-11 signaling as a potential therapeutic target for the treatment of gastrointestinal cancers."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2013.06.017"xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ccr.2013.06.017"xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Horst D."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Horst D."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Heath J.K."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Heath J.K."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Wilson N.J."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Wilson N.J."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Kile B.T."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Kile B.T."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Ernst M."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Ernst M."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Edwards K.M."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Edwards K.M."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Boussioutas A."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Boussioutas A."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Busuttil R.A."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Busuttil R.A."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "McKenzie B.S."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "McKenzie B.S."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Farid R."xsd:string |
| http://purl.uniprot.org/citations/23948300 | http://purl.uniprot.org/core/author | "Farid R."xsd:string |