| http://purl.uniprot.org/citations/23950223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23950223 | http://www.w3.org/2000/01/rdf-schema#comment | "Widespread anti-inflammatory actions of glucocorticoid hormones are mediated by the glucocorticoid receptor (GR), a ligand-dependent transcription factor of the nuclear receptor superfamily. In conjunction with its corepressor GR-interacting protein-1 (GRIP1), GR tethers to the DNA-bound activator protein-1 and NF-κB and represses transcription of their target proinflammatory cytokine genes. However, these target genes fall into distinct classes depending on the step of the transcription cycle that is rate-limiting for their activation: Some are controlled through RNA polymerase II (PolII) recruitment and initiation, whereas others undergo signal-induced release of paused elongation complexes into productive RNA synthesis. Whether these genes are differentially regulated by GR is unknown. Here we report that, at the initiation-controlled inflammatory genes in primary macrophages, GR inhibited LPS-induced PolII occupancy. In contrast, at the elongation-controlled genes, GR did not affect PolII recruitment or transcription initiation but promoted, in a GRIP1-dependent manner, the accumulation of the pause-inducing negative elongation factor. Consistently, GR-dependent repression of elongation-controlled genes was abolished specifically in negative elongation factor-deficient macrophages. Thus, GR:GRIP1 use distinct mechanisms to repress inflammatory genes at different stages of the transcription cycle."xsd:string |
| http://purl.uniprot.org/citations/23950223 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1309898110"xsd:string |
| http://purl.uniprot.org/citations/23950223 | http://purl.uniprot.org/core/author | "Adelman K."xsd:string |
| http://purl.uniprot.org/citations/23950223 | http://purl.uniprot.org/core/author | "Rogatsky I."xsd:string |
| http://purl.uniprot.org/citations/23950223 | http://purl.uniprot.org/core/author | "Muse G.W."xsd:string |
| http://purl.uniprot.org/citations/23950223 | http://purl.uniprot.org/core/author | "Chinenov Y."xsd:string |
| http://purl.uniprot.org/citations/23950223 | http://purl.uniprot.org/core/author | "Gupte R."xsd:string |
| http://purl.uniprot.org/citations/23950223 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23950223 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/23950223 | http://purl.uniprot.org/core/pages | "14616-14621"xsd:string |
| http://purl.uniprot.org/citations/23950223 | http://purl.uniprot.org/core/title | "Glucocorticoid receptor represses proinflammatory genes at distinct steps of the transcription cycle."xsd:string |
| http://purl.uniprot.org/citations/23950223 | http://purl.uniprot.org/core/volume | "110"xsd:string |
| http://purl.uniprot.org/citations/23950223 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23950223 |
| http://purl.uniprot.org/citations/23950223 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23950223 |
| http://purl.uniprot.org/uniprot/#_A0A077S2U6-mappedCitation-23950223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23950223 |
| http://purl.uniprot.org/uniprot/#_D3Z280-mappedCitation-23950223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23950223 |
| http://purl.uniprot.org/uniprot/#_D3YWY4-mappedCitation-23950223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23950223 |
| http://purl.uniprot.org/uniprot/#_A0A5H1ZRL3-mappedCitation-23950223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23950223 |
| http://purl.uniprot.org/uniprot/#_A0A571BG81-mappedCitation-23950223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23950223 |
| http://purl.uniprot.org/uniprot/#_A0A385HBV1-mappedCitation-23950223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23950223 |
| http://purl.uniprot.org/uniprot/#_A0A494B9W1-mappedCitation-23950223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23950223 |
| http://purl.uniprot.org/uniprot/#_A0A8I4SX76-mappedCitation-23950223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23950223 |
| http://purl.uniprot.org/uniprot/#_A6P3E3-mappedCitation-23950223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23950223 |
| http://purl.uniprot.org/uniprot/#_A8CSZ8-mappedCitation-23950223 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23950223 |