| http://purl.uniprot.org/citations/23951051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23951051 | http://www.w3.org/2000/01/rdf-schema#comment | "Natalizumab inhibits the transmigration of activated T lymphocytes into the brain and is highly efficacious in multiple sclerosis (MS). However, from a pharmacogenomic perspective, its efficacy and safety in specific patients remain unclear. Here our goal was to analyze the effects of epithelial V-like antigen (EVA) on anti-alpha₄ integrin (VLA4) efficacy in a mouse model of MS, experimental autoimmune encephalomyelitis (EAE). EVA has been previously characterized in human CD4 T lymphocytes, mouse thymic development, and choroid plexus epithelial cells. Further analysis here demonstrated expression in B lymphocytes and an increase in EVA⁺ lymphocytes following immunization. Following active induction of EAE using the MOG³⁵⁻⁵⁵ active immunization model, EVA deficient mice developed more severe EAE and white matter tissue injury as compared to wild type controls. This severe EAE phenotype did not respond to anti-VLA4 treatment. In both the control antibody and anti-VLA4 conditions, these mice demonstrated persistent CNS invasion of mature B lymphocyte (CD19⁺, CD21⁺, sIgG⁺), increased serum autoantibody levels, and extensive complement and IgG deposition within lesions containing CD5⁺IgG⁺ cells. Wild type mice treated with control antibody also demonstrated the presence of CD19⁺, CD21⁺, sIgG⁺ cells within the CNS during peak EAE disease severity and detectable serum autoantibody. In contrast, wild type mice treated with anti-VLA4 demonstrated reduced serum autoantibody levels as compared to wild type controls and EVA-knockout mice. As expected, anti-VLA4 treatment in wild type mice reduced the total numbers of all CNS mononuclear cells and markedly decreased CD4 T lymphocyte invasion. Treatment also reduced the frequency of CD19⁺, CD21⁺, sIgG⁺ cells in the CNS. These results suggest that anti-VLA4 treatment may reduce B lymphocyte associated autoimmunity in some individuals and that EVA expression is necessary for an optimal therapeutic response. We postulate that these findings could optimize the selection of treatment responders."xsd:string |
| http://purl.uniprot.org/citations/23951051 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0070954"xsd:string |
| http://purl.uniprot.org/citations/23951051 | http://purl.uniprot.org/core/author | "Lanker S."xsd:string |
| http://purl.uniprot.org/citations/23951051 | http://purl.uniprot.org/core/author | "Wright E."xsd:string |
| http://purl.uniprot.org/citations/23951051 | http://purl.uniprot.org/core/author | "Carrithers M.D."xsd:string |
| http://purl.uniprot.org/citations/23951051 | http://purl.uniprot.org/core/author | "Rahgozar K."xsd:string |
| http://purl.uniprot.org/citations/23951051 | http://purl.uniprot.org/core/author | "Hallworth N."xsd:string |
| http://purl.uniprot.org/citations/23951051 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23951051 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23951051 | http://purl.uniprot.org/core/pages | "e70954"xsd:string |
| http://purl.uniprot.org/citations/23951051 | http://purl.uniprot.org/core/title | "Epithelial V-like antigen mediates efficacy of anti-alpha(4) integrin treatment in a mouse model of multiple sclerosis."xsd:string |
| http://purl.uniprot.org/citations/23951051 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/23951051 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23951051 |
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| http://purl.uniprot.org/uniprot/#_O70255-mappedCitation-23951051 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23951051 |
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