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http://purl.uniprot.org/citations/23953521http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/23953521http://www.w3.org/2000/01/rdf-schema#comment"

Aim

The first aim of that study was to investigate HLA class I and class II allele and haplotype frequencies in renal dialysis patients who live in East Anatolia in Turkey. Our second aim was to investigate whether there was a relationship between ABO and D blood group antigens and HLA alleles and haplotypes for the study group.

Materials and methods

HLA class I and II polymorphisms in 408 renal dialysis patients were studied using sequence-specific primers (SSP) and sequence-specific oligonucleotides (SSO). Blood group antigens were detected by agglutination methods on microplates.

Results

A total of 16 HLA-A, 34 HLA-B, and 15 HLA-DRB1 alleles were identified. The most frequent HLA-A alleles were HLA-A*02, HLA-A*24, and HLA-A*11. The most frequent HLA-B alleles were HLA-B*35, HLA-B*51, and HLA-B*44. In case of HLA-DRB1; HLA-DRB1*11, HLA-DRB1*04, and HLA-DRB1*13 were first 3 alleles with higher frequency, in order. In the combination of those 3 alleles, the most frequent HLA-A-B-DRB1 haplotypes were HLA-A*02-B*51-DRB1*11, HLA-A*11-B*35-DRB1*11, A*24-B*35-DRB1*11. The frequency of ABO, D blood group antigens were observed as 0.168 for A Rh(+), 0.019 for A Rh(-), 0.057 for B Rh(+), 0.013 for B Rh(-), 0.123 for O Rh(+), 0.014 for O Rh(-), 0.018 for AB Rh(+), and 0.001 for AB Rh(-). While A Rh(+) samples with HLA-A*02 and HLA-DRB1*11 had the highest frequencies (0.067 and 0.088, respectively), O Rh(+) samples with HLA-B*51 had the highest frequency (0.06).

Conclusion

According to haplotype frequencies HLA-A*02-B*51-DRB1*11 is also found at higher frequencies in Bulgarian and Armenian populations. In case of HLA-associated diseases, the east Anatolian population could be susceptible to myastenia gravis, Behçet's disease, and systemic sclerosis due to the high frequencies of HLA-A*24, HLA-B*51, and HLA-DRB1*11 respectively. We did not observe a correlation between blood group antigens and HLA alleles or haplotypes in renal dialysis patients."xsd:string
http://purl.uniprot.org/citations/23953521http://purl.org/dc/terms/identifier"doi:10.1016/j.transproceed.2013.03.034"xsd:string
http://purl.uniprot.org/citations/23953521http://purl.uniprot.org/core/author"Unal B."xsd:string
http://purl.uniprot.org/citations/23953521http://purl.uniprot.org/core/author"Taskapan H."xsd:string
http://purl.uniprot.org/citations/23953521http://purl.uniprot.org/core/author"Sahin I."xsd:string
http://purl.uniprot.org/citations/23953521http://purl.uniprot.org/core/author"Kayhan B."xsd:string
http://purl.uniprot.org/citations/23953521http://purl.uniprot.org/core/author"Kurtoglu E.L."xsd:string
http://purl.uniprot.org/citations/23953521http://purl.uniprot.org/core/author"Otlu G."xsd:string
http://purl.uniprot.org/citations/23953521http://purl.uniprot.org/core/author"Piskin T."xsd:string
http://purl.uniprot.org/citations/23953521http://purl.uniprot.org/core/date"2013"xsd:gYear
http://purl.uniprot.org/citations/23953521http://purl.uniprot.org/core/name"Transplant Proc"xsd:string
http://purl.uniprot.org/citations/23953521http://purl.uniprot.org/core/pages"2123-2128"xsd:string
http://purl.uniprot.org/citations/23953521http://purl.uniprot.org/core/title"HLA-A, -B, -DRB1 allele and haplotype frequencies and comparison with blood group antigens in dialysis patients in the East Anatolia region of Turkey."xsd:string
http://purl.uniprot.org/citations/23953521http://purl.uniprot.org/core/volume"45"xsd:string
http://purl.uniprot.org/citations/23953521http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/23953521
http://purl.uniprot.org/citations/23953521http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/23953521
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