| http://purl.uniprot.org/citations/23954132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23954132 | http://www.w3.org/2000/01/rdf-schema#comment | "Liver fibrosis is a consequence of chronic liver diseases and thus a major cause of mortality and morbidity. Clinical evidence and animal studies suggest that local tissue homeostasis is disturbed due to immunological responses to chronic hepatocellular stress. Poorly defined stress-associated inflammatory networks are thought to mediate gradual accumulation of extracellular-matrix components, ultimately leading to fibrosis and liver failure. Here we have reported that hepatic expression of interleukin-33 (IL-33) was both required and sufficient for severe hepatic fibrosis in vivo. We have demonstrated that IL-33's profibrotic effects related to activation and expansion of liver resident innate lymphoid cells (ILC2). We identified ILC2-derived IL-13, acting through type-II IL-4 receptor-dependent signaling via the transcription factor STAT6 and hepatic stellate-cell activation, as a critical downstream cytokine of IL-33-dependent pathologic tissue remodeling and fibrosis. Our data reveal key immunological networks implicated in hepatic fibrosis and support the concept of modulation of IL-33 bioactivity for therapeutic purposes."xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2013.07.018"xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://purl.uniprot.org/core/author | "Walker J."xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://purl.uniprot.org/core/author | "Waldner M."xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://purl.uniprot.org/core/author | "Neurath M.F."xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://purl.uniprot.org/core/author | "Schuchmann M."xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://purl.uniprot.org/core/author | "Pflanz S."xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://purl.uniprot.org/core/author | "McKenzie A.N."xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://purl.uniprot.org/core/author | "Wirtz S."xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://purl.uniprot.org/core/author | "Voehringer D."xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://purl.uniprot.org/core/author | "Rankin A.L."xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://purl.uniprot.org/core/author | "McHedlidze T."xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://purl.uniprot.org/core/author | "Zopf S."xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23954132 | http://purl.uniprot.org/core/name | "Immunity"xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://purl.uniprot.org/core/pages | "357-371"xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://purl.uniprot.org/core/title | "Interleukin-33-dependent innate lymphoid cells mediate hepatic fibrosis."xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://purl.uniprot.org/core/volume | "39"xsd:string |
| http://purl.uniprot.org/citations/23954132 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23954132 |
| http://purl.uniprot.org/citations/23954132 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23954132 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RNW1-mappedCitation-23954132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23954132 |
| http://purl.uniprot.org/uniprot/#_A0A0U1RPZ6-mappedCitation-23954132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23954132 |
| http://purl.uniprot.org/uniprot/#_A2VCP1-mappedCitation-23954132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23954132 |
| http://purl.uniprot.org/uniprot/#_D3Z6T7-mappedCitation-23954132 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23954132 |