| http://purl.uniprot.org/citations/23954414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23954414 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23954414 | http://www.w3.org/2000/01/rdf-schema#comment | "The molecular mechanism of autophagy and its relationship to other lysosomal degradation pathways remain incompletely understood. Here, we identified a previously uncharacterized mammalian-specific protein, Beclin 2, which, like Beclin 1, functions in autophagy and interacts with class III PI3K complex components and Bcl-2. However, Beclin 2, but not Beclin 1, functions in an additional lysosomal degradation pathway. Beclin 2 is required for ligand-induced endolysosomal degradation of several G protein-coupled receptors (GPCRs) through its interaction with GASP1. Beclin 2 homozygous knockout mice have decreased embryonic viability, and heterozygous knockout mice have defective autophagy, increased levels of brain cannabinoid 1 receptor, elevated food intake, and obesity and insulin resistance. Our findings identify Beclin 2 as a converging regulator of autophagy and GPCR turnover and highlight the functional and mechanistic diversity of Beclin family members in autophagy, endolysosomal trafficking, and metabolism."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.07.035"xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2013.07.035"xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Dong X."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Dong X."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "He C."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "He C."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Grishin N.V."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Grishin N.V."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Liu Y."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Khan S."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Khan S."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Li B."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Levine B."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Levine B."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Wei Y."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Wei Y."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Sinha S."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Sinha S."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Kinch L.N."xsd:string |
| http://purl.uniprot.org/citations/23954414 | http://purl.uniprot.org/core/author | "Kinch L.N."xsd:string |