| http://purl.uniprot.org/citations/23961995 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23961995 | http://www.w3.org/2000/01/rdf-schema#comment | "BackgroundNeurons in sympathetic ganglia and neuroendocrine cells in the adrenal medulla share not only their embryonic origin from sympathoadrenal precursors in the neural crest but also a range of functional features. These include the capacity for noradrenaline biosynthesis, vesicular storage and regulated release. Yet the regulation of neuronal properties in early neuroendocrine differentiation is a matter of debate and the developmental expression of the vesicle fusion machinery, which includes components found in both neurons and neuroendocrine cells, is not resolved.ResultsAnalysis of synaptic protein and pan-neuronal marker mRNA expression during mouse development uncovers profound differences between sympathetic neurons and adrenal chromaffin cells, which result in qualitatively similar but quantitatively divergent transcript profiles. In sympathetic neurons embryonic upregulation of synaptic protein mRNA follows early and persistent induction of pan-neuronal marker transcripts. In adrenal chromaffin cells pan-neuronal marker expression occurs only transiently and synaptic protein messages remain at distinctly low levels throughout embryogenesis. Embryonic induction of synaptotagmin I (Syt1) in sympathetic ganglia and postnatal upregulation of synaptotagmin VII (Syt7) in adrenal medulla results in a cell type-specific difference in isoform prevalence. Dicer 1 inactivation in catecholaminergic cells reduces high neuronal synaptic protein mRNA levels but not their neuroendocrine low level expression. Pan-neuronal marker mRNAs are induced in chromaffin cells to yield a more neuron-like transcript pattern, while ultrastructure is not altered.ConclusionsOur study demonstrates that remarkably different gene regulatory programs govern the expression of synaptic proteins in the neuronal and neuroendocrine branch of the sympathoadrenal system. They result in overlapping but quantitatively divergent transcript profiles. Dicer 1-dependent regulation is required to establish high neuronal mRNA levels for synaptic proteins and to maintain repression of neurofilament messages in neuroendocrine cells."xsd:string |
| http://purl.uniprot.org/citations/23961995 | http://purl.org/dc/terms/identifier | "doi:10.1186/1749-8104-8-16"xsd:string |
| http://purl.uniprot.org/citations/23961995 | http://purl.uniprot.org/core/author | "Rohrer H."xsd:string |
| http://purl.uniprot.org/citations/23961995 | http://purl.uniprot.org/core/author | "Huber K."xsd:string |
| http://purl.uniprot.org/citations/23961995 | http://purl.uniprot.org/core/author | "Narasimhan P."xsd:string |
| http://purl.uniprot.org/citations/23961995 | http://purl.uniprot.org/core/author | "Unsicker K."xsd:string |
| http://purl.uniprot.org/citations/23961995 | http://purl.uniprot.org/core/author | "Stubbusch J."xsd:string |
| http://purl.uniprot.org/citations/23961995 | http://purl.uniprot.org/core/author | "Ernsberger U."xsd:string |
| http://purl.uniprot.org/citations/23961995 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23961995 | http://purl.uniprot.org/core/name | "Neural Dev"xsd:string |
| http://purl.uniprot.org/citations/23961995 | http://purl.uniprot.org/core/pages | "16"xsd:string |
| http://purl.uniprot.org/citations/23961995 | http://purl.uniprot.org/core/title | "Synaptic protein and pan-neuronal gene expression and their regulation by Dicer-dependent mechanisms differ between neurons and neuroendocrine cells."xsd:string |
| http://purl.uniprot.org/citations/23961995 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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