| http://purl.uniprot.org/citations/23962978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23962978 | http://www.w3.org/2000/01/rdf-schema#comment | "Regulation of cell growth is a fundamental process in development and disease that integrates a vast array of extra- and intracellular information. A central player in this process is RNA polymerase I (Pol I), which transcribes ribosomal RNA (rRNA) genes in the nucleolus. Rapidly growing cancer cells are characterized by increased Pol I-mediated transcription and, consequently, nucleolar hypertrophy. To map the genetic network underlying the regulation of nucleolar size and of Pol I-mediated transcription, we performed comparative, genome-wide loss-of-function analyses of nucleolar size in Saccharomyces cerevisiae and Drosophila melanogaster coupled with mass spectrometry-based analyses of the ribosomal DNA (rDNA) promoter. With this approach, we identified a set of conserved and nonconserved molecular complexes that control nucleolar size. Furthermore, we characterized a direct role of the histone information regulator (HIR) complex in repressing rRNA transcription in yeast. Our study provides a full-genome, cross-species analysis of a nuclear subcompartment and shows that this approach can identify conserved molecular modules."xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.org/dc/terms/identifier | "doi:10.1126/scisignal.2004145"xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/author | "Hu Y."xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/author | "Perrimon N."xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/author | "Winston F."xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/author | "Andrews B."xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/author | "Gross T."xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/author | "Rosebrock A.P."xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/author | "Sharifpoor S."xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/author | "Neumuller R.A."xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/author | "Samsonova A.A."xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/author | "Vinayagam A."xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/author | "Buckner M."xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/author | "Founk K."xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/name | "Sci Signal"xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/pages | "ra70"xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/title | "Conserved regulators of nucleolar size revealed by global phenotypic analyses."xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/23962978 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23962978 |
| http://purl.uniprot.org/citations/23962978 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23962978 |
| http://purl.uniprot.org/uniprot/P32480#attribution-593D91F3FCD52FF3343F953FB7D6CAD4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23962978 |
| http://purl.uniprot.org/uniprot/P32479#attribution-593D91F3FCD52FF3343F953FB7D6CAD4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/23962978 |
| http://purl.uniprot.org/uniprot/#_A0A0B4KFP2-mappedCitation-23962978 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23962978 |