| http://purl.uniprot.org/citations/23964094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23964094 | http://www.w3.org/2000/01/rdf-schema#comment | "Senescence is a stress-responsive form of stable cell cycle exit. Senescent cells have a distinct gene expression profile, which is often accompanied by the spatial redistribution of heterochromatin into senescence-associated heterochromatic foci (SAHFs). Studying a key component of the nuclear lamina lamin B1 (LMNB1), we report dynamic alterations in its genomic profile and their implications for SAHF formation and gene regulation during senescence. Genome-wide mapping reveals that LMNB1 is depleted during senescence, preferentially from the central regions of lamina-associated domains (LADs), which are enriched for Lys9 trimethylation on histone H3 (H3K9me3). LMNB1 knockdown facilitates the spatial relocalization of perinuclear H3K9me3-positive heterochromatin, thus promoting SAHF formation, which could be inhibited by ectopic LMNB1 expression. Furthermore, despite the global reduction in LMNB1 protein levels, LMNB1 binding increases during senescence in a small subset of gene-rich regions where H3K27me3 also increases and gene expression becomes repressed. These results suggest that LMNB1 may contribute to senescence in at least two ways due to its uneven genome-wide redistribution: first, through the spatial reorganization of chromatin and, second, through gene repression."xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.217281.113"xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/author | "Kimura H."xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/author | "Perez-Mancera P.A."xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/author | "Chong H."xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/author | "Chandra T."xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/author | "Bennett D.C."xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/author | "Narita M."xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/author | "Salama R."xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/author | "Young A.R."xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/author | "Sadaie M."xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/author | "Carroll T."xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/author | "Narita M.'"xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/author | "Tomimatsu K."xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/name | "Genes Dev"xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/pages | "1800-1808"xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/title | "Redistribution of the Lamin B1 genomic binding profile affects rearrangement of heterochromatic domains and SAHF formation during senescence."xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://purl.uniprot.org/core/volume | "27"xsd:string |
| http://purl.uniprot.org/citations/23964094 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/23964094 |
| http://purl.uniprot.org/citations/23964094 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/23964094 |
| http://purl.uniprot.org/uniprot/#_A0A0D9SFE5-mappedCitation-23964094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23964094 |
| http://purl.uniprot.org/uniprot/#_P10412-mappedCitation-23964094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23964094 |
| http://purl.uniprot.org/uniprot/#_P52926-mappedCitation-23964094 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/23964094 |