| http://purl.uniprot.org/citations/23965929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23965929 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitsugumin 53 (MG53) negatively regulates skeletal myogenesis by targeting insulin receptor substrate 1 (IRS-1). Here, we show that MG53 is an ubiquitin E3 ligase that induces IRS-1 ubiquitination with the help of an E2-conjugating enzyme, UBE2H. Molecular manipulations that disrupt the E3-ligase function of MG53 abolish IRS-1 ubiquitination and enhance skeletal myogenesis. Skeletal muscles derived from the MG53-/-mice show an elevated IRS-1 level with enhanced insulin signalling, which protects the MG53-/-mice from developing insulin resistance when challenged with a high-fat/high-sucrose diet. Muscle samples derived from human diabetic patients and mice with insulin resistance show normal expression of MG53, indicating that altered MG53 expression does not serve as a causative factor for the development of metabolic disorders. Thus, therapeutic interventions that target the interaction between MG53 and IRS-1 may be a novel approach for the treatment of metabolic diseases that are associated with insulin resistance."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.org/dc/terms/identifier | "doi:10.1038/ncomms3354"xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Lee J.S."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Lee H."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Lee S.H."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Park S.Y."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Hong J."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Song H.K."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Tan T."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Zhu H."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Shin H."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Kim Y.K."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Nguyen N."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Park K.S."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Lee C.S."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Park J.S."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Lin P."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Choi C.S."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Cho H."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Jeong B.C."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Choi I."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Ko Y.G."xsd:string |
| http://purl.uniprot.org/citations/23965929 | http://purl.uniprot.org/core/author | "Kim B.W."xsd:string |