| http://purl.uniprot.org/citations/23967313 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/23967313 | http://www.w3.org/2000/01/rdf-schema#comment | "The c-fos gene responds to extracellular stimuli and undergoes robust but transient transcriptional activation. Here we show that heterogeneous nuclear ribonucleoprotein R (hnRNP R) facilitates transcription reinitiation of the c-fos promoter in vitro in cooperation with Mediator. Consistently, hnRNP R interacts with the Scaffold components (Mediator, TBP, and TFIIH) as well as TFIIB, which recruits RNA polymerase II (Pol II) and TFIIF to Scaffold. The cooperative action of hnRNP R and Mediator is diminished by the cyclin-dependent kinase 8 (CDK8) module, which is comprised of CDK8, Cyclin C, MED12 and MED13 of the Mediator subunits. Interestingly, we find that the length of the G-free cassettes, and thereby their transcripts, influences the hnRNP R-mediated facilitation of reinitiation. Indeed, indicative of a possible role of the transcript in facilitating transcription reinitiation, the RNA transcript produced from the G-free cassette interacts with hnRNP R through its RNA recognition motifs (RRMs) and arginine-glycine-glycine (RGG) domain. Mutational analyses of hnRNP R indicate that facilitation of initiation and reinitiation requires distinct domains of hnRNP R. Knockdown of hnRNP R in mouse cells compromised rapid induction of the c-fos gene but did not affect transcription of constitutive genes. Together, these results suggest an important role for hnRNP R in regulating robust response of the c-fos gene."xsd:string |
| http://purl.uniprot.org/citations/23967313 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0072496"xsd:string |
| http://purl.uniprot.org/citations/23967313 | http://purl.uniprot.org/core/author | "Shimada M."xsd:string |
| http://purl.uniprot.org/citations/23967313 | http://purl.uniprot.org/core/author | "Nishimura K."xsd:string |
| http://purl.uniprot.org/citations/23967313 | http://purl.uniprot.org/core/author | "Fukuda A."xsd:string |
| http://purl.uniprot.org/citations/23967313 | http://purl.uniprot.org/core/author | "Hisatake K."xsd:string |
| http://purl.uniprot.org/citations/23967313 | http://purl.uniprot.org/core/author | "Nakadai T."xsd:string |
| http://purl.uniprot.org/citations/23967313 | http://purl.uniprot.org/core/date | "2013"xsd:gYear |
| http://purl.uniprot.org/citations/23967313 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/23967313 | http://purl.uniprot.org/core/pages | "e72496"xsd:string |
| http://purl.uniprot.org/citations/23967313 | http://purl.uniprot.org/core/title | "Heterogeneous nuclear ribonucleoprotein R cooperates with mediator to facilitate transcription reinitiation on the c-Fos gene."xsd:string |
| http://purl.uniprot.org/citations/23967313 | http://purl.uniprot.org/core/volume | "8"xsd:string |
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